芪龙活络方联合温阳针灸法治疗气虚血瘀型脑梗死恢复期患者的效果观察OA
Efficacy Observation on Qilong Huoluo Formula Combined with Wenyang Acupuncture in Treating Cerebral Infarction Patients at Recovery Stage with Qi Deficiency and Blood Stasis Syndrome
目的:探讨芪龙活络方联合温阳针灸法治疗气虚血瘀型脑梗死恢复期患者的效果.方法:选取 2025 年 3～10 月于本院就诊的80 例气虚血瘀型脑梗死恢复期患者,采用随机数字表法分为对照组和观察组,每组40 例.对照组患者给予常规治疗,观察组在对照组基础上采用芪龙活络方联合温阳针灸法治疗,两组均连续治疗4周.比较两组临床疗效、中医证候评分、运动功能(采用Fugl-Meyer功能评定量表评价)、生活质量[采用脑卒中生存质量量表(SS-QOL)评价]、血液流变学指标(血浆黏度、全血高切黏度及全血低切黏度)、神经相关指标[5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)]及不良反应发生情况.结果:治疗后,观察组患者临床治疗总有效率(92.50%)高于对照组(70.00%,P＜0.05).观察组患者中医证候评分、血浆黏度、全血高切黏度、全血低切黏度和血清 NSE 均低于对照组,Fugl-Meyer评分(上肢和下肢)、SS-QOL评分、血清5-HT和BDNF均高于对照组(P＜0.05).两组患者不良反应总发生率比较无统计学差异(P＞0.05).结论:芪龙活络方联合温阳针灸法可提高气虚血瘀型脑梗死恢复期患者的临床疗效,降低血液黏度,调节神经相关指标水平,改善运动功能,提高生活质量.
Objective:To explore the clinical effect of Qilong Huoluo Formula combined with Wenyang Acupuncture in the treatment of cerebral infarction patients at recovery stage with qi deficiency and blood stasis syndrome.Methods:A total of 80 cerebral infarction patients at recovery stage with qi deficiency and blood stasis syndrome admitted from March to October 2025 were selected and divided into control group and observation group by random number table method,with 40 cases in each group.The control group received conventional treatment;the observation group was treated with Qilong Huoluo Formula combined with Wenyang Acupuncture on the basis of the control group,with continuous treatment for 4 weeks.Clinical efficacy,traditional Chinese medicine(TCM)syndrome score,motor function(evaluated by the Fugl-Meyer Assessment Scale),quality of life[evaluated by the Stroke-Specific Quality of Life(SS-QOL)],hemorheological indexes(plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity),neuro-related indicators[5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE)]and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.50%,higher than 70.00%of the control group(P<0.05).TCM syndrome score,plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity and serum NSE in the observation group were lower than those of the control group;Fugl-Meyer score(upper limb and lower limb),SS-QOL score,serum 5-HT and BDNF were higher than those of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Qilong Huoluo Formula combined with Wenyang Acupuncture can improve clinical efficacy,reduce blood viscosity,regulate neuro-related indicators levels,and improve motor function and quality of life in cerebral infarction patients at recovery stage with qi deficiency and blood stasis syndrome.
赵敏;范晓飞;段云飞;张新慧;韩文刚;唐然
荥阳市中医院脑病二科,荥阳 450100河南中医药大学第一附属医院,郑州 450000荥阳市中医院脑病二科,荥阳 450100荥阳市中医院脑病二科,荥阳 450100荥阳市中医院脑病二科,荥阳 450100荥阳市中医院脑病二科,荥阳 450100
医药卫生
脑梗死恢复期气虚血瘀型芪龙活络方温阳针灸法
cerebral infarctionrecovery stageqi deficiency and blood stasis syndromeQilong Huoluo FormulaWenyang Acupuncture
《中国合理用药探索》 2026 (5)
119-126,8
河南省中医药科学研究专项课题(2022ZY1026)
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