氨酚羟考酮对肺癌患者胸腔镜肺段切除术后疼痛的控制效果分析OA

Objective:To explore the effect of oxycodone-paracetamol on postoperative pain control in lung cancer patients undergoing thoracoscopic pulmonary segmentectomy.Methods:A total of 60 patients with lung cancer undergoing elective thoracoscopic pulmonary segmentectomy from August 2022 to June 2025 were prospectively enrolled and divided by envelope method into control group and observation group,with 30 cases in each group.The control group received routine postoperative analgesia,and the observation group was given oxycodone-paracetamol tablets on the basis of routine analgesia.Postoperative visual analogue scale(VAS)score,analgesic pump pressing times within 24 h after operation,total sufentanil dosage within 24 h after operation,pain mediators(substance P,β-endorphin,5-hydroxytryptamine),inflammatory indicators[interleukin-6(IL-6),high mobility group protein B1(HMGB1)],sleep quality and adverse reactions were compared between the two groups.Results:The VAS scores at 12 h,24 h and 48 h after operation in the observation group were lower than those in the control group(P<0.05).The total pressing times of analgesic pump within 24 h and total sufentanil dosage within 24 h after operation were less than those in the control group(P<0.05).At 24 h after operation,the levels of substance P,β-endorphin,5-hydroxytryptamine,IL-6 and HMGB1 increased in both groups,with lower levels in the observation group(P<0.05).The total sleep time,deep sleep time and light sleep time were shortened in both groups,but longer in the observation group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Oxycodone-paracetamol has good effect on pain control after thoracoscopic pulmonary segmentectomy in lung cancer patients.It can inhibit the elevation of pain mediators and inflammatory indicators,reduce the impact on sleep quality,with good safety.