18α-甘草酸的合成工艺研究OA
Study on synthetic process of 18α-glycyrrhizic acid
优化18α-甘草酸的合成工艺.以18β-甘草酸单铵盐为起始原料,经异构化、酯化和水解反应得到目标化合物18α-甘草酸.目标化合物及关键中间体的结构经1H NMR、13C NMR和 HRMS确证,目标化合物的总收率为 9.43%,纯度为 99.23%,杂质 A的含量为 0.17%.优化后的工艺显著提高了异构化转化率,降低了有关物质的生成,简化了纯化工序,更有利于工业化生产和成本控制.
In this study,the synthetic process of 18α-glycyrrhizic acid was optimized.Using 18β-glycyrrhizic acid monoammonium salt as the starting material,the target compound 18α-glycyrrhizic acid was obtained through isomerization,esterification,and hydrolysis,with a total yield of 9.43%,purity of 99.23%and key impurity A of 0.17%(HPLC).The optimized process significantly improved the isomerization conversion rate,reduced the formation of related substances,simplified the purification steps,and enhanced both industrial scalability and cost efficiency.
李宇兴;马学燕;赵轲;赵佳星
兰州交通大学生物与制药工程学院,兰州 730070兰州交通大学生物与制药工程学院,兰州 730070兰州交通大学生物与制药工程学院,兰州 730070兰州交通大学生物与制药工程学院,兰州 730070
医药卫生
18α-甘草酸合成工艺优化
18α-glycyrrhizic acidsynthesisprocess optimization
《中国药科大学学报》 2026 (3)
288-294,7
This work was supported by the Science and Technology Program of Gansu Province(25CXGA029),and the National Natural Science Foundation of China(No.82560852)甘肃省科技专员专项(25CXGA029)国家自然科学基金项目(No.82560852)
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