首页|期刊导航|癌症生物学与医学(英文版)|Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left-and right-sided colorectal neoplasia

Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left-and right-sided colorectal neoplasiaOA

Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left-and right-sided colorectal neoplasia

Sunny H.Wong;Marc T.L.Wong;Louis H.S.Lau;Rashid N.S.Lui;Raymond S.Y.Tang;James Y.W.Lau;Simon S.M.Ng;Jun Yu;Joseph J.Y.Sung;Thomas N.Y.Kwong;Ru Zhang;Thomas Y.T.Lam;Andrew M.Y.Ho;Wing Wah Leung;Xing Kang;Harry C.H.Lau;Eagle S.H.Chu

Centre for Microbiome Medicine,Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 308232,Singapore||Department of Gastroenterology and Hepatology,Tan Tock Seng Hospital,National Healthcare Group,Singapore 308433,SingaporeInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaDepartment of Surgery,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaDepartment of Surgery,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China||CUHK-Shenzhen Research Institute,Shenzhen 518057,ChinaCentre for Microbiome Medicine,Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 308232,Singapore||Department of Gastroenterology and Hepatology,Tan Tock Seng Hospital,National Healthcare Group,Singapore 308433,SingaporeInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China||Shenzhen People's Hospital,Shenzhen 518020,ChinaThe Nethersole School of Nursing,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaDepartment of Surgery,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaCentre for Microbiome Medicine,Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 308232,Singapore||Institute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,ChinaInstitute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China

Colorectal cancercolorectal adenomascolon carcinogenesiscolonic microfloragut microbiome

Colorectal cancercolorectal adenomascolon carcinogenesiscolonic microfloragut microbiome

《癌症生物学与医学(英文版)》 2026 (5)

755-768,14

The work was supported by the Singapore National Medical Research Council Clinician Scientist Individual Research Grant(Grant No.CIRG23jan-0004),Large Collaborative Grant(Grant Nos.OFLCG22may-0009,OFLCG23may-0031,and OFLCG24may-0025),and the Wang Lee Wah Memorial Fund.

10.20892/j.issn.2095-3941.2025.0846

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