餐前饮水疗法对老年餐后低血压患者血压波动的影响OA

Objective To investigate the effects of pre-meal water intake therapy on blood pressure(BP)fluctuations and cardiovascular and cerebrovascular events in older patients with postprandial hypotension(PPH)and to provide evidence for non-pharmacological mana-gement of PPH.Methods In this randomized controlled trial,300 older patients with PPH were randomly assigned to an observation group(routine treatment plus 400 mL warm water 30 min before meals)and control group(routine treatment alone),with 150 patients in each group.The lowest systolic(SBP)and diastolic blood pressure(DBP)values before daily three meals and within 2 h after each meal were compared between the two groups before treatment as well as 6 months after treatment.Cardiovascular and cerebrovascular events were documented during the 6-month follow-up period.Kaplan-Meier survival analysis was performed to evaluate the intervention effect.Results No statistically significant differences were observed in baseline SBP or DBP between the two groups(both P>0.05)before treatment.The observation group showed significantly reduced postprandial SBP fluctuations 6 months after treatment compared with those in the control group(P<0.001),whereas no significant difference was observed in DBP(P>0.05).During the 6-month follow-up period,the total incidence of cardiovascular and cerebrovascular events was significantly lower in the observation group than in the control group(P=0.014 5).Conclusion Pre-meal water intake therapy effectively reduces postprandial SBP fluctuations and lowers the risk of cardiovascular and cerebrovascular events in older patients with PPH,showing favorable safety.Therefore,it can be recommended as a non-pharmacological treatment option in clinical practice.