巨噬细胞调控脓毒症免疫功能的机制与中西医干预研究进展OA

Sepsis is a life-threatening systemic inflammatory response syndrome triggered by infection.Its pathogenesis is complex,involving the abnormal activation and interaction across multiple systems and pathways.Despite advancements in critical care,its clinical mortality remains persistently high,posing a significant challenge in the field of intensive care medicine.As the first line of defense in the human innate immune system,macrophages serve as not only the core effector cells of innate immunity but also a critical bridge connecting innate and adaptive immunity.Throughout the entire process of sepsis onset,progression,and resolution,macrophages play an indispensable role in immune regulation.This review systematically explores the intricate interplay between macrophages and sepsis,focusing on the impact of macrophage dysfunction on overall immune function in sepsis and the underlying molecular and cellular mechanisms.The content primarily covers key aspects such as macrophage polarization imbalance,autophagy dysregulation,uncontrolled cell death,metabolic reprogramming,and other potential mechanisms.Through layered and multi-angle analysis of these mechanisms,this article aims to comprehensively elucidate the central role of macrophages in the immune imbalance of sepsis.This provides a solid theoretical foundation for future efforts to precisely and timely regulate macrophage function and restore host immune homeostasis.Additionally,it aims to explore innovative research directions and strategies for developing novel targeted therapies and interventions tailored to different pathological stages of sepsis,including the early hyperinflammatory phase and the later immunosuppressive phase.