肺炎支原体肺炎患者支气管肺泡灌洗液中铁蛋白水平与塑型性支气管炎的相关性OA
Correlation between ferritin levels in bronchoalveolar lavage fluid and plastic bronchitis in patients with Mycoplasma pneumoniae pneumonia
目的 探讨支气管肺泡灌洗液(BALF)中铁蛋白水平与肺炎支原体肺炎(MPP)严重程度的相关性及其对塑型性支气管炎(PB)的预测价值.方法 回顾性分析121例MPP患者的临床资料,根据病情严重程度,分为非重症MPP组(NSMPP组,74例)和重症MPP组(SMPP组,47例);根据支气管镜下表现,分为PB组(39 例)和非PB组(NPB组,82例).选取同期治疗的14例支气管异物患者为对照组.采用酶联免疫吸附试验检测 BALF中铁蛋白水平,比较各组间铁蛋白和临床指标的差异.结果 SMPP组BALF中铁蛋白水平显著高于NSMPP组(P<0.001),PB组BALF中铁蛋白水平显著高于NPB组(P<0.001).MPP患者BALF中铁蛋白水平显著高于支气管异物患者(P<0.001).结论 BALF中铁蛋白水平能反映MPP的严重程度,是PB发生的独立危险因素.
Objective To investigate the correlation between ferritin levels in bronchoalveolar lavage fluid(BALF)and the severity of Mycoplasma pneumoniae pneumonia(MPP),as well as its predictive value for plastic bronchitis(PB).Methods A retrospective ana-lysis was conducted on the clinical data of 121 patients with MPP.Based on clinical presentation,the patients were divided into non-se-vere MPP(NSMPP)group(74 cases)and severe MPP(SMPP)group(47 cases).According to bronchoscopic findings,they were further classified into a PB group(39 cases)and a non-PB(NPB)group(82 cases).A control group of 14 patients with bronchial foreign bodies admitted during the same period was selected.Ferritin levels in BALF were measured using an enzyme-linked immunosorbent assay,and differences in ferritin levels and clinical indicators among groups were compared.Results Ferritin levels in BALF were signifi-cantly higher in the SMPP group compared to the NSMPP group(P<0.001),and significantly higher in the PB group compared to the NPB group(P<0.001).Ferritin levels in BALF were significantly higher in patients with MPP than in those with bronchial foreign bodies(P<0.001).Conclusion Ferritin levels in BALF reflect the severity of MPP and represent an independent risk factor for PB.
张宇;刘雪;王志远;展效文;李树军
河南医药大学第一附属医院儿童重症监护室,河南 新乡 453100||菏泽医学专科学校附属医院儿科,山东 菏泽 274000河南医药大学第一附属医院儿童重症监护室,河南 新乡 453100河南医药大学第一附属医院儿童重症监护室,河南 新乡 453100河南医药大学第一附属医院儿童重症监护室,河南 新乡 453100河南医药大学第一附属医院儿童重症监护室,河南 新乡 453100
医药卫生
肺炎支原体肺炎铁蛋白塑型性支气管炎支气管肺泡灌洗液
Mycoplasma pneumoniae pneumoniaferritinplastic bronchitisbronchoalveolar lavage fluid
《中国医科大学学报》 2026 (6)
517-521,5
河南省2023年医学科技攻关计划联合共建项目(LHGJ20230520)
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