增强型体外反搏对心力衰竭合并认知障碍患者的疗效研究OA
Effect of Enhanced External Counterpulsation on Quality of Life,Cardiac Function,and Cognitive Function in Patients with Heart Failure and Cognitive Impairment
目的:观察增强型体外反搏(enhanced external counterpulsation,EECP)对心力衰竭合并认知障碍患者生活质量、心功能及认知功能的影响.方法:选取 2024 年 10 月—2025 年 1 月就诊于河北北方学院附属第一医院 90 例心力衰竭合并认知障碍患者随机分为对照组和观察组各 45 例,对照组给予心衰常规治疗,观察组在此基础联合EECP.治疗 7 周后比较两组明尼苏达心力衰竭生活质量问卷(Minnesota living with heart failure questionnaire,MLHFQ)、左室射血分数(left ventricular ejection fraction,LVEF)、6 分钟步行试验距离(6-minute walking distance,6MWD)、舒张早期与晚期充盈速度比值(E/A值)、纽约心功能分级(New York heart association,NYHA分级)、左室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)、N末端脑钠肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、30 天再住院率、日常生活活动能力(activities of daily living,ADL)量表评分、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评分的差异.结果:治疗后,两组MLHFQ评分均下降,观察组下降更显著(P<0.05).心功能方面,观察组LVEF、6MWD、E/A值及NYHA分级改善更优,LVEDD、NT-proBNP及hsCRP下降幅度大于对照组(P<0.05),但两组 30 天再住院率差异无统计学意义(P>0.05).认知方面,观察组MoCA评分升高,ADL评分改善优于对照组(P<0.05);对照组MoCA评分无显著变化.结论:EECP有益于心力衰竭合并认知障碍患者的生活质量、心功能及认知功能改善.
Objective:To observe the effects of enhanced external counterpulsation(EECP)on quality of life,cardiac function,and cognitive function in patients with heart failure complicated cognitive impairment.Methods:Ninety patients were randomly assigned to either a control group or an observation group,with 45 patients in each.The control group received standard heart failure treatment,while the observation group received EECP in addition to the standard treatment.After 7 weeks of treatment,comparisons were made between the two groups regarding the Minnesota living with heart failure questionnaire(MLHFQ)score,left ventricular ejection fraction(LVEF),6-minute walking distance(6MWD),ratio of early to late diastolic ventricular filling velocities(E/A ratio),New York Heart Association(NYHA)functional classification,left ventricular end-diastolic dimension(LVEDD),N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels,high-sensitivity C-reactive protein(hs-CRP)levels,30-day readmission rate,activities of daily living(ADL)scale score,and Montreal cognitive assessment(MoCA)score.Results:After treatment,the MLHFQ scores decreased in both groups,with a more significant decrease observed in the EECP group(P<0.05).Regarding cardiac function,the EECP group showed superior improvement in LVEF,6MWD,E/A ratio,and NYHA classification,as well as a greater reduction in LVEDD,NT-proBNP,and hs-CRP levels compared to the control group(P<0.05).However,no statistically significant difference was found in the 30-day readmission rate between the two groups(P>0.05).Regarding cognitive function,the MoCA scores increased and ADL scores improved more significantly in the EECP group compared to the control group(P<0.05);the control group showed no significant change in MoCA scores.Conclusion:EECP is beneficial for improving quality of life,cardiac function,and cognitive function in patients with heart failure complicated by cognitive impairment.
刘加齐;李方江;秦少强;张爱爱;王子帅
河北北方学院研究生学院,张家口,075000,中国河北北方学院附属第一医院心血管内科,张家口,075000,中国河北北方学院附属第一医院心血管内科,张家口,075000,中国河北北方学院附属第一医院心血管内科,张家口,075000,中国河北北方学院研究生学院,张家口,075000,中国
医药卫生
增强型体外反搏心力衰竭认知障碍疗效评估
enhanced external counterpulsationheart failurecognitive impairmenttherapeutic evaluation
《神经药理学报》 2026 (2)
29-35,7
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