nab-PC方案联合固金消瘤煎在老年肺鳞癌治疗中的效果观察OA
Observation on the Effect of nab-PC Regimen Combined with Gujin Xiaoliu Decoction in the Treatment of the Elderly with Lung Squamous Carcinoma
目的:探讨白蛋白结合型紫杉醇联合卡铂(nab-PC)方案联合固金消瘤煎治疗老年肺鳞癌的效果及安全性.方法:选取 2023 年 1 月—2025 年 6 月松原市中西医结合医院收治的 62 例老年肺鳞癌患者,依据随机数字表法分为试验组(n=31,nab-PC方案联合固金消瘤煎)和对照组(n=31,nab-PC方案).两组均以 21 d为 1 个周期,共治疗 6 个周期.比较两组临床疗效、生存质量、肿瘤标志物、生长因子、趋化因子及不良反应.结果:治疗后,试验组客观缓解率(54.84%)高于对照组(29.03%)(P<0.05).治疗后,两组癌症治疗功能评价系统-肺癌模块(FACT-L)各维度评分均较治疗前升高,试验组高于对照组(P<0.05).治疗后,两组肿瘤标志物水平均较治疗前下降,试验组癌胚抗原(CEA)、鳞状细胞癌抗原(SCCA)、细胞角蛋白 19 片段(CYFRA21-1)水平低于对照组(P<0.05).治疗后,两组生长因子、趋化因子水平均较治疗前下降,试验组血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、血小板源性生长因子(PDGF)、CC 趋化因子配体 5(CCL5)、CC 趋化因子配体 20(CCL20)水平低于对照组(P<0.05).两组血小板减少、中性粒细胞减少、白细胞减少、贫血、恶心呕吐发生率及疾病控制率比较,差异无统计学意义(P>0.05).结论:nab-PC 方案联合固金消瘤煎可提高老年肺鳞癌患者的客观缓解率,改善生活质量,且不增加不良反应发生风险.
Objective:To explore the efficacy and safety of nab-Paclitaxel-Carboplatin(nab-PC)regimen combined with Gujin Xiaoliu Decoction in the treatment of the elderly with lung squamous carcinoma.Method:A total of 62 elderly patients with lung squamous carcinoma who were admitted to Songyuan Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to June 2025 were selected.According to the random number table method,the patients were divided into the experimental group(n=31,nab-PC regimen combined with Gujin Xiaoliu Decoction)and the control group(n=31,nab-PC regimen).Both groups were treated for 6 cycles,with each cycle lasting 21 days.The clinical efficacy,quality of life,tumor markers,growth factors,chemokines and adverse reactions between the two groups were compared.Result:After treatment,the objective response rate of the experimental group(54.84%)was higher than that of the control group(29.03%)(P<0.05).After treatment,the scores of each dimension of the functional assessment of cancer therapy-lung(FACT-L)in both groups were higher than those before treatment,and those of experimental group were higher than those of the control group(P<0.05).After treatment,the levels of tumor markers in both groups decreased compared to before treatment,the levels of carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCCA),and cytokeratin 19 fragment(CYFRA21-1)in the experimental group were lower than those in the control group(P<0.05).After treatment,the levels of growth factors and chemokines in both groups decreased compared to before treatment,the levels of vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF),CC chemokine ligand 5(CCL5),and CC chemokine ligand 20(CCL20)in the experimental group were lower than those in the control group(P<0.05).There were no statistically significant differences in the incidence rates of thrombocytopenia,neutropenia,leukopenia,anemia,nausea and vomiting,and disease control rate between the two groups(P>0.05).Conclusion:The nab-PC regimen combined with Gujin Xiaoliu Decoction can significantly increase the objective response rate of elderly patients with lung squamous carcinoma,improve quality of life,and does not increase the risk of adverse reactions.
陈丽芝;刘立平;贾旭迪;杨洪辉
松原市中西医结合医院肿瘤科 吉林 松原 138000松原市中西医结合医院肿瘤科 吉林 松原 138000松原市中西医结合医院心血管内科 吉林 松原 138000松原市中西医结合医院肿瘤科 吉林 松原 138000
医药卫生
白蛋白结合型紫杉醇卡铂固金消瘤煎老年肺鳞癌
Nab-PaclitaxelCarboplatinGujin Xiaoliu DecoctionElderly lung squamous carcinoma
《中国医学创新》 2026 (13)
16-21,6
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