电针介导免疫调节在神经危重症高危静脉血栓栓塞症患者深静脉血栓形成预防中的作用OA

Objective To explore the therapeutic effect and potential mechanism of electroacupuncture-mediated immunomodulation in the prevention of deep vein thrombosis(DVT)in high-risk patients with venous thromboembolism(VTE)in neurocritical care.Methods A total of 71 patients with neurocritical illness admitted to the emergency intensive care unit(EICU)of our hospital from January 2024 to January 2025 were selected were enrolled.The patients were randomly allocated to a control group(36 cases)and the experimental group(35 cases)using a random-number table.Both groups received symptomatic and supportive treatments such as anti-infection and nutritional fluid infusion.The control group was given bilateral lower extremity pneumatic therapy,while the experimental group was given electroacupuncture treatment on the basis of the control group,with the combination of acupoints such as Zusanli(ST36),Shangjuxu(ST37),Hegu(LI4),and Quchi(LI11).Both groups were treated for 14 days.The general data[gender,age,Glasgow coma scale(GCS)score],inflammatory indicators[including white blood cell count(WBC),neutrophil count(NEU),lymphocyte count(LYM),neutrophil-to-lymphocyte ratio(NLR),monocyte count(MON),lymphocyte-to-monocyte ratio(LMR),C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)],immune indicators[including immunoglobulin(IgA,IgG,IgM),complement components(C3,C4)],and the incidence of DVT were compared between the two groups.Results There were no statistically significant differences in WBC,NEU,LYM,NLR,MON,LMR,CRP,PCT,IL-6,IgA,IgG,IgM,C3,and C4 between the two groups before treatment(all P>0.05).After 14 days of treatment,the NLR in the control group decreased significantly compared with that before treatment[7.83(5.42,13.39)vs.11.24(5.98,18.56),P<0.05],while in the experimental group,WBC,NEU,NLR,and IL-6 decreased significantly compared with those before treatment[WBC(×109/L):9.18(7.08,11.55)vs.10.48(8.20,16.31),NEU(×109/L):6.50(5.45,8.15)vs.8.63(6.60,13.70),NLR(%):5.20(3.96,10.87)vs.9.00(6.34,12.89),IL-6(pg/ml):36.13(15.86,63.84)vs.123.43(46.03,212.45),all P<0.05].IgA,IgG,IgM,and C3 increased significantly compared with those before treatment[IgA(g/L):2.69(1.96,3.37)vs.1.78(1.27,2.28),IgG(g/L):11.53(9.51,14.45)vs.10.30(8.59,11.60),IgM(g/L):1.12(0.95,1.43)vs.0.84(0.59,1.17),C3(g/L):1.15±0.28 vs.0.85±0.25,all P<0.05].Moreover,the NLR and the incidence of DVT in the experimental group were significantly lower than those in the control group[NLR(%):5.20(3.96,10.87)vs.7.83(5.42,13.39),DVT incidence:31.43%vs.55.56%,P<0.05],and IgM and C3 were significantly higher than those in the control group[IgM(g/L):1.12(0.95,1.43)vs.0.94(0.69,1.14),C3(g/L):1.15±0.28 vs.0.98±0.19,all P<0.05].Conclusion Electroacupuncture may lower the incidence of DVT by modulating systemic immune and inflammatory response,providing a certain theoretical basis for DVT prevention in this setting.