皮质下梗死伴白质脑病的常染色体显性遗传性脑动脉病伴自发性脑出血的研究进展OA

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a common hereditary cerebral small vessel disease.Its typical clinical features include migraine with aura and recurrent ischemic stroke,while its potential manifestation of spontaneous intracerebral hemorrhage(ICH)is often overlooked.CADASIL patients with ICH have high rates of stroke recurrence,disability,and mortality,which significantly impacts their prognosis.This article systematically examined the epidemiological and imaging characteristics,risk factors,specific clinical manifestations,pathological mechanisms and treatment strategies for CADASIL with ICH,with the aim of providing a reference for the development of individualized management strategies in clinical practice.