儿童异基因造血干细胞移植后吉兰-巴雷综合征1例并文献复习OA
Guillain-Barré syndrome following allogeneic hematopoietic stem cell transplantation in a pediatric patient:a case report and literature review
患儿,女,10岁,因诊断高IgE综合征6年余,造血干细胞移植后4月余,头晕伴肢体乏力1周就诊.患儿于移植后第121天出现头晕及进行性、对称性肢体无力.脑脊液检查提示蛋白-细胞分离,肌电图证实为多发性周围神经损害,诊断为吉兰-巴雷综合征.该患儿对静脉注射免疫球蛋白治疗反应不佳,但对糖皮质激素治疗反应良好.经治疗后,患儿神经系统症状完全缓解,后续出现重度慢性移植物抗宿主病.该文在该病例基础上对相关文献进行复习与总结,旨在为该病的早期诊断、机制探讨及治疗选择提供参考.
A 10-year-old girl diagnosed with hyper-IgE syndrome for more than six years developed dizziness and symmetrical progressive limb weakness one week prior to hospital admission,occurring 4 months after allogeneic hematopoietic stem cell transplantation.On post-transplant day 121,dizziness and progressive,symmetric limb weakness appeared.Cerebrospinal fluid analysis revealed albuminocytologic dissociation.Electromyography confirmed multiple peripheral nerve lesions,consistent with the diagnosis of Guillain-Barré syndrome.Intravenous immunoglobulin therapy showed limited efficacy,whereas corticosteroid therapy produced significant clinical improvement.Neurological symptoms fully resolved after treatment;however,severe chronic graft-versus-host disease occurred subsequently.Based on this case,related literature was reviewed and summarized to provide references for early diagnosis,mechanistic investigation,and treatment options.
吕佳忆;周小辉;王春静;杨春兰;罗明静;刘四喜
深圳市儿童医院血液肿瘤科,广东 深圳 518000深圳市儿童医院血液肿瘤科,广东 深圳 518000深圳市儿童医院血液肿瘤科,广东 深圳 518000深圳市儿童医院血液肿瘤科,广东 深圳 518000深圳市儿童医院血液肿瘤科,广东 深圳 518000深圳市儿童医院血液肿瘤科,广东 深圳 518000
异基因造血干细胞移植吉兰-巴雷综合征移植物抗宿主病儿童
Allogeneic hematopoietic stem cell transplantationGuillain-Barré syndromeGraft-versus-host diseaseChild
《中国当代儿科杂志》 2026 (6)
763-767,5
深圳市医疗卫生"三名工程"(SZSM202211033)广东省高水平临床重点专科(深圳市配套建设经费)(SZGSP012).
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