猪子宫内膜上皮细胞与胚胎着床互作机制的研究进展OA

In large-scale pig production,the core goal of reducing production costs is to increase the number of sows per year and the number of live litters,while the low efficiency of maternal embryo implantation is the key bottleneck restricting this goal.Endometrial epithelial cells(EECs)are the"first interface"for embryo attachment,and their functional status directly affects embryo survival.The existing studies on the relationship between endometrial epithelial cells and embryo implantation mostly focus on infertility and abortion in humans or mice,while the mechanism analysis in pigs is insufficient.This article systematically reviews the dynamic functional characteristics of EECs under the regulation of hormones,focusing on the mechanism of embryo implantation mediated by adhesion molecules,growth factors,chemokines and immune factors,and exploring the regulatory effect of EECs on endometrial receptivity,in order to provide a theoretical basis for optimizing the reproductive efficiency of pigs.