药食同源物质在慢性功能性便秘预防和调理中的研究进展OA

Chronic functional constipation(CFC)is a type of functional bowel disorder with a long course and a high recurrence rate.Long-term illness can bring various harms and lead to serious consequences.Long-term use of Western medicine is prone to drug dependence and complications.Food-medicine homologous substances provide a new approach for the treatment of CFC.At present,studies on food-medicine homologous substances for treating CFC still lack systematic review.Accordingly,this article synthesizes relevant domestic and international research findings to explore the application value and research progress of food-medicine homologous substances in the prevention and management of CFC.It systematically summarizes their core mechanisms,including regulating intestinal microecology,modulating aquaporins,and balancing gastrointestinal neurotransmitters.Meanwhile,the limitations of current research are also identified:lack of analyses on the overall synergistic effects of these mechanisms,small sample sizes and a lack of multi center,long term follow up data,and insufficient studies on interactions between food-medicine homologous substances and modern drugs.Future research directions are also prospected.This review aims to provide a reference for clinical intervention and the optimization of dietary therapy for CFC.