针灸多靶点协同调控慢性阻塞性肺疾病免疫炎性稳态的研究进展OA

The pathological development of chronic obstructive pulmonary disease(COPD)is closely related to the imbalance of immune-inflammatory homeostasis,mainly involving the dysregulation of T helper(Th)cell subset homeostasis,imbalance of inflammatory cell networks,cytokine storm,regulation of inflammatory signaling pathways,activation of the cholinergic anti-inflammatory pathway,autophagy-mediated inflammatory response,and regulation of other inflammatory pathways.Through the multidimensional regulatory network of"acupoint-nerve-immunity",acupuncture can simultaneously act on multiple key nodes such as the cholinergic anti-inflammatory pathway,kinase-mediated inflammatory response pathways,to remodel Th17/regulatory T lymphocyte(Treg)balance,and regulation of macrophage classical activation(M1)/alternative activation(M2)polarization,demonstrating superior homeostasis-regulating characteristics.This article systematically reviews the latest research progress on acupuncture in the multi-target synergistic regulation of immune-inflammatory homeostasis in COPD,aiming to provide evidence for the integrated treatment of COPD.