基于文献计量学的益母草碱研究现状与研究热点分析OA

Objective To investigate the research status of leonurine,the active alkaloid of Leonurus japonicus,and to study the hotspots and development trends in this field.Methods Relevant literatures of China National Knowledge Infrastructure(CNKI)and Science Citation Index Database(WoS)up to July 2024 were retrieved.CiteSpace software was used to analyze the information of the included literatures,such as the number of publications,countries,institutions,authors,highly cited literatures and keywords,and to generate a knowledge map.Results A total of 193 Chinese literatures and 179 English literatures were included,and the annual number of publications increased steadily.The country with the largest number of publications was China,followed by Singapore and the United States;the institution with the largest number of papers was Fudan University,forming a core author group centered on Zhu,YiZhun(ZHU Yizhun).The Chinese and English journals with the most literature were China Journal of Chinese Materia Medicaand International Immunopharmacology,respectively.Leonurine had pharmacological uses such as protecting cardiovascular,kidney,and uterine systems,as well as anti-oxidative stress,anti-inflammation,and anti-tumor.The research hotspots and frontiers mainly focused on the regulation and molecular mechanism of leonurine on inflammation,cell proliferation and apoptosis,and the signaling pathway NF-kappaB was highly concerned.Conclusion The research on leonurine has formed a China-centered international cooperation network and gradually developed.However,the exchanges and cooperation among institutions and authors are insufficient and need to be strengthened.The related mechanism of leonurine is worthy of further exploration,and the drug safety and efficacy of leonurine need to be further confirmed.