胃癌化学预防:阿司匹林、二甲双胍等经典药物的希望与挑战OACHSSCD
Gastric cancer chemoprevention:hopes and challenges of aspirin,metformin,and other classic drugs
胃癌是全球范围内常见的恶性肿瘤之一,每年有近一半的胃癌新发病例和死亡病例发生在中国.幽门螺杆菌(Hp)感染是胃癌的主要危险因素,但根除Hp并不能完全预防胃癌的发生.近年来,阿司匹林、环氧化酶2抑制剂、二甲双胍及他汀类药物与胃癌风险的关系受到广泛关注.系统梳理上述药物与胃癌风险的流行病学证据、潜在作用机制及临床转化前景,并对未来研究方向提出展望.
Gastric cancer is one of the most common malignant neoplasms worldwide,with nearly half of all new cases and deaths occurring in China annually.Helicobacter pylori(Hp)infection is a major risk factor for gastric cancer;however,Hp eradication does not completely prevent the occurrence of gastric cancer.In recent years,the relationship between aspirin,cyclooxygenase-2 inhibitors,metformin,and statins and the risk of gastric cancer has garnered substantial attention.The epidemiological evidence,potential mechanisms of action,and clinical translation prospects of these drugs in relation to gastric cancer risk are systematically reviewed,and future research directions are proposed.
李嵩博;时永全
空军军医大学西京医院消化内科,国家消化系统疾病临床医学研究中心,消化系肿瘤整合防治全国重点实验室,陕西西安 710032空军军医大学西京医院消化内科,国家消化系统疾病临床医学研究中心,消化系肿瘤整合防治全国重点实验室,陕西西安 710032
医药卫生
胃肿瘤化学预防阿司匹林环氧化酶2抑制剂二甲双胍羟甲基戊二酰辅酶A还原酶抑制剂幽门螺杆菌危险因素
stomach neoplasmschemopreventionaspirincyclooxygenase-2 inhibitorsmetforminhydroxymethylglutaryl-CoA reductase inhibitorsHelicobacter pyloririsk factors
《空军军医大学学报》 2026 (6)
781-789,9
国家科技重大专项(2025ZD0545301)陕西省卫生健康科研创新能力提升计划团队支持项目(2024TD-06)
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