亚精胺在卵巢早衰患者中的作用及其研究进展OA
Role of Spermidine in Patients with Premature Ovarian Failure and its Research Progress
卵巢早衰(POF)是一种严重影响女性生育能力的疾病,其病因复杂且多样化,给患者带来了巨大的心理和生理负担.近年来,亚精胺作为一种重要的多胺类化合物,因其在细胞增殖、凋亡及生殖健康方面的潜在作用而受到广泛关注,其可能通过调节卵巢功能、改善细胞氧化应激水平以及促进卵母细胞质量,从而对POF患者产生积极影响.这为亚精胺在POF的研究及临床应用提供了新的思路和方向.本综述探讨了亚精胺与POF之间的关系,并分析了其在POF发病机制中的作用及未来作为潜在治疗策略的前景.
Premature ovarian Failure(POF)is a disease that seriously affects female fertility,with complex and diverse etiologies,bringing tremendous psychological and physiological burdens to patients.In recent years,spermidine,as an important polyamine compound,has received widespread attention due to its potential roles in cell proliferation,apoptosis,and reproductive health.It may have a positive impact on POF patients by regulating ovarian function,improving cell oxidative stress level and promoting oocyte quality.This provides new ideas and directions for the research and clinical application of spermidine in POF.This review discusses the relationship between spermidine and POF,and analyzes its role in the pathogenesis of POF and its prospects as a potential treatment strategy in the future.
张一凡;张国忠;自永宏
攀枝花市妇幼保健院生殖医学中心/攀枝花市生殖医学重点实验室,四川 攀枝花 617000攀枝花市妇幼保健院生殖医学中心/攀枝花市生殖医学重点实验室,四川 攀枝花 617000攀枝花市妇幼保健院生殖医学中心/攀枝花市生殖医学重点实验室,四川 攀枝花 617000
医药卫生
亚精胺卵巢早衰生殖健康细胞增殖氧化应激卵母细胞
SpermidinePremature ovarian failureReproductive healthCell proliferationOxidative stressOocytes
《医学信息》 2026 (11)
179-182,4
攀枝花市指导性科技计划项目(编号:2023ZD-S-32)
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