VEGF与肝纤维化关系的研究进展OA

Liver fibrosis is a repair process of the liver in response to liver injury and is the result of an imbalance between intrahepatic fibrogenesis and fibrolysis during the progression of various chronic liver diseases,leading to excessive collagen deposition within the liver.Liver fibrosis can progress to cirrhosis,seriously threatening human life and health.Vascular endothelial growth factor(VEGF)family is a group of multifunctional cytokines that play important roles in liver protection and regeneration,as well as in angiogenesis and lymphangiogenesis,and can promote endothelial cell proliferation,promote angiogenesis,and increase vascular permeability.Studies have shown that VEGF is one of the important factors leading to the development of liver fibrosis.In recent years,research on the role of VEGF in liver fibrosis has made certain progress both domestically and internationally,providing new theoretical basis for elucidating the pathogenesis of liver fibrosis and for the development of clinical drugs.This article aims to summarize the mechanisms of action by which VEGF induces liver fibrosis in the contexts of inducing HSCs activation,under hepatic hypoxia,during inflammation,and in liver sinusoidal endothelial cells,in order to provide a theoretical basis for scientific research and clinical treatment of anti-fibrosis.