炎性反应-代谢标志物在糖尿病肾病进展中的研究现状OA

diabetic nephropathy(DN)is the most common microvascular complication of diabetic and the primary cause of end stage renal disease(ESRD),which seriously threatens the quality of life of patients.The interaction and crosstalk between metabolic disorders and chronic inflammation are the core pathological mechanisms driving the progression of diabetic nephropathy,forming a vicious cycle of"metabolic abnormalities inflammation amplification renal injury aggrava-tion",and participating in key pathological processes such as glomerulosclerosis and tubulointerstitial fibrosis.Inflammation metabolic markers can simultaneously reflect the metabolic imbalance and inflammatory activation status of the body,covering multiple categories such as classical inflammatory factors,inflammasomes,acute phase response proteins,glucose and lipid metabolites,oxidative stress,and adipokines.They can compensate for the lack of sensitivity and specificity of a single marker and have important value in early warning,disease stratification,prognosis evaluation,and efficacy monitoring of diabetic ne-phropathy.Therefore,elucidating the mechanism of action,detection value,and clinical application of inflammation metabolic markers in the system can provide important basis for early diagnosis,precise intervention,and development of new targets for DN.This article reviews the classification of inflammation metabolic markers,their mechanisms of action in the progression of diabetic nephropathy,their clinical application value,and research prospects.