幽门螺杆菌不同根除治疗方案及影响因素研究进展OA
Research progress on different eradication treatment regimens for Helicobacter pylori and their influencing factors
幽门螺杆菌(Hp)是一种革兰阴性、可传播的人胃内疾病病原体,全球约半数人口为Hp感染者,根除Hp可有效降低胃癌的发生风险.然而,由于Hp现有治疗方案的局限性以及影响根除疗效的多重因素,导致我国根除Hp面临诸多挑战.文章系统梳理了Hp根除治疗方案的一线方案、二线补救治疗及非抗生素替代疗法的研究进展,分析抗生素耐药、CYP2C19基因多态性、患者依从性等影响根除疗效的关键因素.旨在为临床优化Hp根除策略提供参考.
Helicobacter pylori(Hp)is a Gram-negative,transmissible pathogen responsible for human gastric diseases,with approximately half of the global population infected.Eradication of Hp has been proven to effectively reduce the risk of gastric cancer.In China,however,the limitations of current therapeutic regimens and multiple factors influencing treat-ment outcomes have rendered Hp eradication substantially challenging.This review systematically summarizes the progress of first-line therapy,second-line rescue therapy and non-antibiotic alternative strategies for Hp eradication,and discusses key de-terminants of treatment efficacy,including antibiotic resistance,CYP2C19 gene polymorphisms,and patient compliance,with the aim of providing clinical references for optimizing Hp eradication strategies.
谢文丽;杨杰;武胜
550004 贵阳,贵州医科大学临床医学院贵州医科大学附属医院消化内科550004 贵阳,贵州医科大学临床医学院||553000 贵州六盘水,六盘水市人民医院
医药卫生
幽门螺杆菌根除治疗影响因素
Helicobacter pyloriEradication therapyInfluencing factors
《疑难病杂志》 2026 (6)
747-751,755,6
贵阳市科技计划项目(筑科合同[2018]1-85号) Guiyang Science and Technology Program Project(Zhuke Contract[2018]1-85)
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