3-吲哚甲醇抗肿瘤作用的研究进展OA
Progress in the anti-tumor effects of indole-3-carbinol
近年来,3-吲哚甲醇(I3C)引入肿瘤治疗的研究中,在抑制和干扰多种肿瘤的发生、发展方面起了关键作用.本文深入探讨I3C及其在胃酸环境中转化的吲哚衍生物3,3-二吲哚基甲烷(DIM)作为有效的天然化学预防剂抗多种肿瘤的机制.介绍I3C的理化特性及其流行病学研究,强调其安全性和有效性.详细讨论I3C抗肿瘤的分子机制,包括磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素[PI3K/PKB(AKT)/mTOR]和芳香烃受体(AHR)等多种信号通路,为深入I3C的研究提供参考.
In recent years,indole-3-carbinol(I3C)has been introduced into tumor therapy research,playing a key role in inhibiting and interfering with the occurrence and development of various tumors.This article explored the mechanisms by which I3C and its indole-derived metabolite,3,3'-diindolylmethane(DIM),which is converted in the acidic environment of the stomach,serve as effective natural chemopreventive agents against multiple tumors.The physicochemical properties of I3C were presented alongside epidemiological studies,emphasizing its safety and efficacy.Furthermore,it provided a detail discussion of the molecular mechanisms of I3C's anti-tumor effects,including various signaling pathways such as the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin[PI3K/PKB(AKT)/mTOR]and aryl hydrocarbon receptor(AHR)pathways.This article served as a valuable reference for further research on I3C.
王贵民;樊昊;周乐其;温镕博;于冠宇;郝立强;张卫
海军军医大学附属长海医院肛肠外科,上海 200433海军军医大学附属长海医院肛肠外科,上海 200433海军军医大学附属长海医院肛肠外科,上海 200433海军军医大学附属长海医院肛肠外科,上海 200433海军军医大学附属长海医院肛肠外科,上海 200433海军军医大学附属长海医院肛肠外科,上海 200433海军军医大学附属长海医院肛肠外科,上海 200433
医药卫生
3-吲哚甲醇磷脂酰肌醇3-激酶/蛋白激酶B通路芳香烃受体抗肿瘤
Indole-3-carbinol(I3C)Phosphoinositide 3-kinase/protein kinase B[PI3K/PKB(AKT)pathway]Aryl hydrocarbon receptor(AHR)Anti-tumor
《外科理论与实践》 2026 (2)
163-168,6
国家自然科学基金(82072750)
评论