肿瘤相关成纤维细胞在甲状腺癌中的研究进展OA
Advance in cancer-associated fibroblasts in thyroid cancer
甲状腺癌是近年来发病率上升较快的恶性肿瘤之一.肿瘤微环境在癌症发生发展过程中起到重要作用.肿瘤相关成纤维细胞(CAF)是肿瘤微环境的重要组成成分.本文阐述甲状腺癌中CAF的来源、标志物和亚群,以及CAF直接或通过重塑细胞外基质(ECM)促进甲状腺癌发展的两种机制,探讨CAF在甲状腺癌治疗中的潜在靶点,包括阻断癌细胞与CAF之间的相互作用和靶向CAF分泌因子.
Thyroid cancer is one of the most rapidly increasing malignant tumors in recent years.Tumor microenvironment plays an important role in the occurrence and development of cancer.Cancer-associated fibroblasts(CAFs)are an important component of the tumor microenvironment.We summarized the origins,biomarkers,and subpopulations of CAF in thyroid cancer,as well as the two mechanisms by which CAFs promote thyroid cancer either directly or by remodeling the extracellular matrix(ECM).Finally,potential targets of CAF for treating thyroid cancer were discussed,including blocking the interaction between cancer cells and CAF,and targeting CAF-secreted factors.
刘金跃;邱伟华
上海交通大学医学院附属瑞金医院普外科,上海 200025上海交通大学医学院附属瑞金医院普外科,上海 200025
医药卫生
肿瘤相关成纤维细胞甲状腺癌肿瘤微环境细胞外基质
Cancer-associated fibroblast(CAF)Thyroid cancerTumor microenvironment(TME)Extracellular matrix(ECM)
《外科理论与实践》 2026 (2)
158-162,5
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