腹腔镜胃旁路术治疗肥胖合并多囊卵巢综合征疗效荟萃分析OA

Objective To systematically evaluate the therapeutic effect of laparoscopic Roux-en-Y gastric bypass(LRYGB)in patients with obesity comorbid with polycystic ovary syndrome(PCOS).Methods A systematic literature search was conducted across four databases(PubMed,Embase,Web of Science,and Scopus)for studies published up to January 1,2025.Following screening against predefined eligibility criteria,a total of 6 studies comprising 128 patients were ultimately included.Results Following LRYGB,there was a significant reduction in the number of patients with menstrual irregularities(OR=0.07;95％CI:0.04～0.14;P<0.05).Additionally,significant improvements were observed in hirsutism(OR=0.14;95％CI:0.06～0.32;P<0.05),sex hormone-binding globulin(SHBG)(MD=23.24;95％CI:7.97～38.51;P<0.05),free androgen index(FAI)(MD=-3.89;95％CI:-5.33～-2.45;P<0.05),total testosterone levels(MD=-25.55;95％CI:-30.08～-21.01;P<0.05),and body mass index(BMI)(MD=-17.22;95％CI:-19.32～-15.11;P<0.000 1).Conclusions LRYGB can serve as an effective therapeutic intervention to improve body weight and metabolic profiles in the population with obesity comorbid with PCOS.