结直肠癌化疗:基石地位巩固与精准化发展OA

As the cornerstone of systemic treatment for colorectal cancer,chemotherapy(cytotoxic drug therapy)continues to evolve in clinical practice,with its scope and application significantly expanding.In the treatment of advanced disease,the combination of chemotherapy with targeted and immunotherapeutic agents has been continuously optimized,leading to the development of precision treatment strategies tailored to different molecular subtypes,which has markedly improved therapeutic efficacy.In the field of perioperative therapy,the application of neoadjuvant chemotherapy,total neoadjuvant therapy(TNT),and the precision enhancement of adjuvant chemotherapy are reshaping the treatment landscape for patients with resectable colorectal cancer.Furthermore,novel technologies such as circulating tumor DNA offer the potential for prediction and dynamic monitoring of clinical decision and chemotherapy efficacy.From the perspective of chemotherapy,this article systematically analyzed its role in the treatment system for colorectal cancer,and discussed its clinical challenges and future directions.