益生菌通过"肠道-皮肤轴"缓解特应性皮炎机制研究进展OA

[Objective]The important concept of the"gut-skin axis"suggests that gut microbiota and their metabolites can remotely influence skin physiology and inflammatory status through pathways such as immune modulation.In chronic conditions like atopic dermatitis,dysbiosis of the gut microbiome may exacerbate systemic inflammation via the"gut-skin axis,"thereby triggering or worsening the disease.This review systematically summarizes the multidimensional mechanisms by which probiotics modulate atopic dermatitis through the"gut-skin axis"over the past decade,providing a theoretical foundation for microecological prevention and treatment strategies.[Methods]A systematic review approach was employed to search and analyze relevant literature from the past ten years,focusing on key aspects including immune regulation,skin barrier restoration,microbial metabolism,and the novel vitamin A pathway.[Results]Probiotics can positively regulate the"gut-skin axis"by modulating immune balance,suppressing pathogenic bacteria,repairing the skin barrier,and influencing the vitamin A pathway,thereby alleviating inflammatory manifestations in atopicdermatitis.[Conclusion]Probiotics exert beneficial effects on atopic dermatitis via the"gut-skin axis,"supporting the use of microecological interventions as a theoretical basis for its prevention and management.