植物来源纳米囊泡在炎症性疾病治疗中的研究进展OA

Inflammatory diseases are a group of disorders characterized by aberrant activation,chronic persistence,or impaired resolution of inflammatory responses as key pathological features.Current anti-inflammatory drugs are limited by obvious adverse ef-fects after long-term use,a high risk of immunosuppression,relatively narrow therapeutic targets,and substantial interindividual vari-ability in efficacy.Plant-derived nanovesicles(PDNVs)have attracted increasing attention in the intervention of inflammatory diseases owing to their broad availability,good biocompatibility,structural stability,and intrinsic enrichment of diverse bioactive components,in-cluding lipids,proteins,nucleic acids,and secondary metabolites.These properties enable PDNVs to participate in inflammatory regu-lation through multi-target synergistic effects.This review systematically summarizes the compositional characteristics,functional ad-vantages,and research progress of PDNVs in inflammatory diseases,including inflammatory bowel disease,skin inflammation,osteoar-thritis,neurodegenerative diseases,acute lung injury,and acute kidney injury.Furthermore,the potential mechanisms and translational challenges of PDNVs from different plant sources are discussed,with the aim of providing a reference for in-depth mechanistic studies and preclinical development of PDNVs.