温肾化瘀安冲方治疗肾阳虚痰湿血瘀型多囊卵巢综合征的临床研究OA

OBJECTIVE To evaluate the effects of Wenshen Huayu Anchong Recipe(WSAR)on spontaneous ovulation and menstrual recovery in patients with polycystic ovary syndrome(PCOS)characterized by kidney yang deficiency,phlegm-dampness,and blood stasis pattern.METHODS From April 2023 to February 2025,a total of 64 women with kidney yang deficiency,phlegm-dampness,and blood stasis pattern PCOS who visited the Traditional Chinese Medicine Gynecology Clinic of Jiangxi University of Chi-nese Medicine Affiliated Hospital were enrolled.Participants were randomly assigned,using a random number table,to the treatment group(n=32)or the control group(n=32).The treatment group received the WSAR,while the control group received a placebo.Both groups were treated for 3 months,with a 1-month follow-up after treatment.During the study,3 patients in the treatment group and 7 patients in the control group withdrew.Changes in traditional Chinese medicine syndrome scores,anxiety,and depression(HADS),sexual function(FSFI),and quality of life(PCOSQ)were evaluated before and after treatment.Clinical manifestations of hyperandrogen-ism,including hirsutism,acne,and hair loss,were also assessed.Serum sex hormone levels[follicle-stimulating hormone(FSH),lutein-izing hormone(LH),estradiol(E2),prolactin(PRL),and total testosterone(T)]were measured using ELISA;fasting blood glucose(FBG),total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL-C),and low-density lipoprotein(LDL-C)were measured by en-zymatic assay;fasting insulin(FINS)was measured by chemiluminescence immunoassay(CLIA),and the homeostasis model assessment of insulin resistance(HOMA-IR)was calculated.Adverse events were monitored during treatment,and spontaneous ovulation was as-sessed after treatment.RESULTS After 3 months of treatment,the treatment group showed significant improvement from baseline in TCM syndrome score,menstrual cycle length,acne score,LH,LH/FSH ratio,T,FINS,HOMA-IR,PCOSQ,and FSFI scores(P<0.01),whereas no significant changes were observed in the control group.Between-group comparisons indicated that the treatment group had a significantly higher monthly spontaneous ovulation rate and significantly higher PCOSQ and FSFI scores than the control group(P<0.05,P<0.01).Additionally,the treatment group had significantly lower TCM syndrome score,menstrual cycle length,acne score,LH,LH/FSH ratio,T,FINS,and HOMA-IR compared with the control group(P<0.05,P<0.01).No obvious adverse reactions were observed in either group during treatment.CONCLUSION The WSAR effectively increases the spontaneous ovulation rate in women with PCOS characterized by kidney yang deficiency,phlegm-dampness,and blood stasis pattern,while improving serum hormone lev-els,reducing traditional Chinese medicine syndrome scores,alleviating insulin resistance,enhancing quality of life,and demonstrating good safety.