血浆同型半胱氨酸、脂联素水平和高血压患者认知功能障碍程度的相关性研究OA
Study on the correlation between plasma homocysteine and adiponectin levels and the degree of cognitive dysfunction in patients with hypertension center for community
目的 探讨血浆同型半胱氨酸(Hcy)、脂联素(ADPN)水平和高血压患者认知功能障碍程度的相关性.方法 选取2024 年6 月至2025 年6 月我院收治的180 例高血压患者,依据是否发生认知功能障碍分为认知功能障碍组、认知功能正常组,收集并对比两组患者性别、年龄、血压、既往疾病史、吸烟史、饮酒史等一般资料情况,并对比血浆 Hcy、ADPN 及总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、尿酸、空腹血糖、餐后2h 血糖、糖化血红蛋白、胰岛素(FINS)等指标.以 Pearson 分析探讨血浆 Hcy、ADPN 水平和高血压患者认知功能障碍程度的相关性.结果 180 例高血压患者的蒙特利尔认知评估量表评分为(24.35±2.96)分,其中得分<26 分者95 例,占比52.78%;根据认知功能障碍程度划分,轻度障碍(22～25 分)32 例、中度障碍(16～21 分)40 例、重度障碍(≤15 分)23 例.依据是否发生认知功能障碍将患者分为认知功能障碍组(n=95)与认知功能正常组(n=85),两组患者在年龄、受教育年限、FINS、Hcy 及 ADPN 水平方面的对比,差异均具有统计学意义(均 P<0.05).多因素 Logistic 回归分析显示,年龄增长、受教育年限缩短、Hcy 水平升高、ADPN 水平下降是高血压患者发生认知功能障碍的独立危险因素(均 P<0.05).随着患者认知功能障碍程度的加重,其 Hcy 水平呈梯度上升趋势,ADPN 水平呈梯度下降趋势(均 P<0.05).Pearson 相关分析结果显示,Hcy 水平与高血压患者认知功能障碍程度呈负相关(r=-0.762,P<0.05),ADPN 水平与高血压患者认知功能障碍程度呈正相关(r=0.721,P<0.05).结论 血浆 Hcy、ADPN 是高血压患者发生认知功能障碍的独立危险因素,临床应重视这两项指标的变化,提早识别认知功能障碍高危患者并采取针对性干预措施.
Objective To explore the correlation between plasma homocysteine(Hcy)and adiponectin(ADPN)levels and the degree of cognitive dysfunction in patients with hypertension.Methods A total of 180 patients with hypertension admitted to our hospital from June 2024 to June 2025 were selected and divided into the cognitive impairment group and cognitive normal group according to the presence of cognitive impairment.General data including gender,age,blood pressure,past disease history,smoking history and drinking history,as well as plasma indicators including Hcy,ADPN,total cholesterol,triglyceride,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,uric acid,fasting plasma glucose,2 h postprandial blood glucose,glycated hemoglobin and insulin(FINS)were collected and compared between the two groups.Pearson correlation analysis was used to explore the correlation between plasma Hcy,ADPN levels and the degree of cognitive impairment in patients with hypertension.Results The Montreal Cognitive Assessment score of 180 patients with hypertension was(24.35±2.96)points,among which 95 cases(52.78%)scored<26 points;according to the degree of cognitive impairment,there were32 cases of mild impairment(22～25 points),40 cases of moderate impairment(16～21 points)and 23 cases of severe impairment(≤15 points).Patients were divided into the cognitive impairment group(n=95)and cognitive normal group(n=85).There were statistically significant differences in age,years of education,FINS,Hcy and ADPN levels between the two groups(all P<0.05).Multivariate Logistic regression analysis showed that increased age,shortened years of education,elevated Hcy level and decreased ADPN level were independent risk factors for cognitive impairment in patients with hypertension(all P<0.05).With the aggravation of cognitive impairment,patients'Hcy level showed a gradient upward trend and ADPN level showed a gradient downward trend(all P<0.05).Pearson correlation analysis showed that Hcy level was negatively correlated with the degree of cognitive impairment in patients with hypertension(r=-0.762,P<0.05),and ADPN level was positively correlated with the degree of cognitive impairment in patients with hypertension(r=0.721,P<0.05).Conclusions Plasma Hcy and ADPN are independent risk factors for cognitive impairment in patients with hypertension.Clinically,attention should be paid to the changes of these two indicators to identify high-risk patients with cognitive impairment early and take targeted intervention measures.
徐立莉;李学斌
200041 上海市静安区南京西路街道社区卫生服务中心全科医学科200041 上海市静安区南京西路街道社区卫生服务中心全科医学科
医药卫生
同型半胱氨酸脂联素高血压认知功能障碍
homocysteineadiponectinhypertensioncognitive dysfunction
《临床神经病学杂志》 2026 (3)
198-202,5
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