中药调控氧化应激治疗胆汁淤积性肝损伤的机制及临床应用OA
Mechanism and clinical application of traditional Chinese medicine in treatment of cholestatic liver injury by regulating oxidative stress
胆汁淤积性肝损伤(CLI)是由多种原因导致胆汁酸在体内异常蓄积引起的肝脏病变,若不及时干预,可逐步进展为肝纤维化、肝硬化、肝衰竭,甚至死亡.研究表明,通过调控氧化应激可减轻脂质过氧化和细胞损伤,进而抑制炎症与细胞凋亡.近年来,中药活性成分及复方在调控氧化应激治疗CLI方面取得积极进展.本文系统总结了中药基于氧化应激调控治疗CLI的作用机制及临床应用研究现状.
Cholestatic liver injury(CLI)is a hepatic disorder characterized by the abnormal accumulation of bile acids in the body due to various etiologies,and without timely intervention,it can progress to liver fibrosis,liver cirrhosis,and liver failure and even lead to death.Studies have shown that modulating oxidative stress can alleviate lipid peroxidation and cellular damage,thereby suppressing inflammation and cell apoptosis.In recent years,remarkable progress has been made regarding the active components and compound prescriptions of traditional Chinese medicine in the treatment of CLI by regulating oxidative stress.This article systematically reviews the current status of research on the mechanism of action and clinical application of traditional Chinese medicine in the treatment of CLI by regulating oxidative stress.
唐银佩;佘琳静;朱正望;王兵;朱平生
河南中医药大学第一临床医学院,郑州 450046河南中医药大学第一临床医学院,郑州 450046河南中医药大学第三附属医院消化科,郑州 450008上海交通大学医学院附属第六人民医院中医科,上海 200240河南中医药大学第一临床医学院,郑州 450046
胆汁淤积氧化性应激中药
CholestasisOxidative StressTraditional Chinese Drugs
《临床肝胆病杂志》 2026 (5)
1229-1235,7
国家自然科学基金(82074340)河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-19)上海市"科学与创新行动计划"自然科学基金面上项目(23ZR1448400) National Natural Science Foundation of China(82074340)Special Project for Scientific Research of Henan Province's"Double First-Class"Creation Discipline of Traditional Chinese Medicine(HSRP-DFCTCM-2023-1-19)Shanghai Science and Innovation Action Plan Natural Science Foundation General Project(23ZR1448400)
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