中药对肝纤维化肝窦毛细血管化的抑制作用及其机制OA
Inhibitory effect and mechanism of traditional Chinese medicine on liver fibrosis and hepatic sinusoidal capillarization
肝窦毛细血管化是肝纤维化发生的先发事件,抑制肝窦毛细血管化能有效改善肝纤维化的病理进程.多项研究证实,中药在抑制肝窦毛细血管化方面作用显著.本文系统综述了相关中药的有效成分、单体及复方,总结其抑制肝窦毛细血管化的作用机制,并从中医角度分析中药干预肝窦毛细血管化的理论依据,旨在为肝纤维化的治疗提供思路补充和文献依据.
Hepatic sinusoidal capillarization is the first event in the process of fibrogenesis,and inhibiting hepatic sinusoidal capillarization can effectively improve the pathological process of liver fibrosis.Various studies have shown that traditional Chinese medicine can significantly inhibit hepatic sinusoidal capillarization.This article systematically reviews the effective constituents,monomers,and compound prescriptions of traditional Chinese medicine,summarizes their mechanism of action in inhibiting hepatic sinusoidal capillarization,and analyzes the theoretical core of traditional Chinese medicine in inhibiting hepatic sinusoidal capillarization from the perspective of traditional Chinese medicine,in order to provide ideas and literature support for the treatment of liver fibrosis.
王龙;马丽;宋安东;李国花;贾婷婷
宁夏医科大学中医学院,银川 750004||宁夏医科大学中医燥证教育部重点实验室,银川 750004宁夏医科大学中医学院,银川 750004||宁夏医科大学中医燥证教育部重点实验室,银川 750004宁夏医科大学中医学院,银川 750004宁夏医科大学中医学院,银川 750004宁夏回族自治区中医医院暨中医研究院,银川 750021
肝纤维化肝窦毛细血管化中草药治疗学
Hepatic FibrosisHepatic Sinusoidal Capillary MetaplasiaDrugs,Chinese HerbalTherapeutics
《临床肝胆病杂志》 2026 (5)
1166-1171,6
宁夏自然科学基金(2023AAC5040)宁夏医科大学校级科研项目(NXT2022015)宁夏医科大学中医学院一流学科建设项目(ZY0019110305) Ningxia Natural Science Foundation(2023AAC5040)Ningxia Medical University Campus Level Scientific Research Project(NXT2022015)Funding From the First Class Discipline Construction Project of the School of Traditional Chinese Medicine,Ningxia Medical University(ZY0019110305)
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