血清白细胞介素-33、可溶性ST2水平与溃疡性结肠炎疾病活动度及肛周病变的关联OA

Objective To investigate the association of serum interleukin-33(IL-33)and solu-ble ST2(sST2)levels with disease activity and perianal lesions in patients with ulcerative colitis(UC).Methods A total of 120 UC patients diagnosed at Zhengzhou Anorectal Hospital from Janu-ary 2021 to December 2025 were enrolled as UC group,and 120 age-and sex-matched healthy volun-teers were recruited as control group.Serum IL-33 and sST2 levels were measured by enzyme-linked immunosorbent assay(ELISA).Blood routine indices,C-reactive protein(CRP)level,and erythro-cyte sedimentation rate(ESR)were detected using corresponding methods.Disease activity was as-sessed using the modified Mayo scoring system for patient stratification,and perianal lesions were identified through clinical examination for group allocation.Intergroup differences were compared.Spearman rank correlation analysis was used to examine the correlations of serum IL-33 and sST2 levels with clinical indices.Multivariate logistic regression analysis was performed to identify inde-pendentfactors associated with perianal lesions in UC patients.Results Serum IL-33 and sST2 lev-els in the UC group were significantly higher than those in the control group(P＜0.001),and both levels and the rates of abnormal elevation showed a stepwise increasing trend with worsening disease activity.The perianal lesion subgroup exhibited significantly higher serum IL-33 levels and abnormal elevationrates but lower sST2 levels compared with the non-perianal lesion subgroup(P＜0.05).Spearman rank correlation analysis revealed that serum IL-33 and sST2 levels were both positively correlated with CRP,ESR,white blood cell count,platelet count,and Mayo score(P＜0.001),and negatively correlated with red blood cell count and hemoglobin level(P＜0.001),showing the strongest correlation between IL-33 and Mayo score(r=0.867).Multivariate logistic regression a-nalysis demonstrated that elevated IL-33 level was an independent risk factor for perianal lesions in UC patients(OR=1.131,P＜0.001),whereas elevated sST2 level served as an independent pro-tective factor(OR=0.897,P＜0.001).Conclusion Serum IL-33 and sST2 levels are closely as-sociated with UC disease activity.IL-33 is an independent risk factor and sST2 is an independent protective factor for perianal lesions.Both biomarkers hold potential value in assessing UC disease activity and predicting perianal lesions.