祛腐生肌散治疗肛瘘术后患者的临床疗效及可能机制OA
Clinical efficacy and possible mechanism of Qufu Shengji Powder in the treatment of patients after anal fistula surgery
目的 探讨祛腐生肌散对肛瘘术后患者的临床疗效及其对缺氧诱导因子-1α(HIF-1α)/血管内皮生长因子(VEGF)信号通路的影响.方法 选取接受手术治疗的148例肛瘘患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组74例.对照组接受常规治疗,观察组接受常规治疗联合祛腐生肌散治疗,疗程1个月.统计2组患者创面愈合情况,评估创面疼痛、肉芽与分泌物评分,并比较肛门功能、炎性因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、临床疗效、不良反应发生率及HIF-1α、VEGF水平.结果 观察组创面愈合时间短于对照组,创面愈合率高于对照组,差异有统计学意义(P＜0.05).治疗前,2组创面疼痛、肉芽与分泌物评分和IL-1 β、TNF-α、IL-6、HIF-1 α、VEGF水平比较,差异无统计学意义(P＞0.05);治疗后,2组创面疼痛、肉芽与分泌物评分和IL-1β、TNF-α、IL-6水平低于治疗前,且观察组低于对照组,差异有统计学意义(P＜0.05);治疗后,2组HIF-1 α、VEGF水平高于治疗前,且观察组高于对照组,差异有统计学意义(P＜0.05).观察组治疗有效率为90.54％,高于对照组的78.38％,差异有统计学意义(P＜0.05).2组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 祛腐生肌散可有效促进肛瘘术后患者创面愈合,具有显著的临床疗效,其作用机制可能与激活HIF-1α/VEGF信号通路有关.
Objective To investigate the clinical efficacy of Qufu Shengji Powder in patients after anal fistula surgery and its impact on the hypoxia-inducible factor-1α(HIF-1 α)/vascular endothelial growth factor(VEGF)signaling pathway.Methods A total of 148 patients with anal fistula who un-derwent surgical treatment were selected as the study subjects.They were randomly divided into control group and observation group using a random number table method,with 74 cases in each group.The control group received conventional treatment,while the observation group received conventional treat-ment combined with Qufu Shengji Powder for a treatment course of 1 month.The wound healing status of patients in the two groups was statistically analyzed.Wound pain,granulation,and secretion scores were evaluated.Anal function,levels of inflammatory factors[interleukin-1 β(IL-1β),tumor necro-sis factor-α(TNF-α),interleukin-6(IL-6)],clinical efficacy,incidence of adverse reactions,and levels of HIF-1 α and VEGF were compared between the two groups.Results The wound healing time in the observation group was shorter than that in the control group,and the wound healing rate was higher than that in the control group,with statistically significant differences(P＜0.05).Before treat-ment,there were no statistically significant differences in wound pain,granulation and secretion scores,and levels of IL-1β,TNF-α,IL-6,HIF-1α,and VEGF between the two groups(P＞0.05).After treatment,the wound pain,granulation and secretion scores,and levels of IL-1β,TNF-α,and IL-6 in both groups were lower than those before treatment,and these values in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).Af-ter treatment,the levels of HIF-1α and VEGF in both groups were higher than those before treat-ment,and these levels in the observation group were higher than those in the control group,with statistically significant differences(P＜0.05).The effective treatment rate in the observation group was 90.54％,which was higher than the 78.38％in the control group,with a statistically signifi-cant difference(P＜0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion Qufu Shengji Powder can ef-fectively promote wound healing in patients after anal fistula surgery and has significant clinical effica-cy.Its mechanism of action may be related to the activation of the HIF-1α/VEGF signaling pathway.
张静;张帅;王佳薇;李敏
川北医学院附属医院中西医结合肛肠科,四川南充,637000川北医学院附属医院中西医结合肛肠科,四川南充,637000川北医学院附属医院中西医结合肛肠科,四川南充,637000川北医学院附属医院中西医结合肛肠科,四川南充,637000
医药卫生
祛腐生肌散肛瘘缺氧诱导因子-1α血管内皮生长因子炎性因子创面愈合中医药疗法不良反应
Qufu Shengji Powderanal fistulahypoxia-inducible factor-1αvascular endothe-lial growth factorinflammatory factorswound healingtraditional Chinese medicine therapyad-verse reactions
《实用临床医药杂志》 2026 (9)
100-104,118,6
四川省医药卫生科技计划项目(3128205A)
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