抗癌小分子前药自组装纳米制剂的研究进展OA

Small molecule drugs play an important role in the treatment of diseases.For many small molecule anticancer drugs,there are widespread shortcomings such as poor targeting,low solubility and poor stability,which seriously limit the clinical application of drugs.Small molecule prodrug self-assembly nanopreparations play an important role in overcoming these shortcomings of drugs.This paper summarizes the latest progress of small-molecule prodrug self-assembly nanopreparations in recent years,including the theoretical basis of self-assembly structure,classification based on prodrug structure,advantages over traditional nanoparticles,"intelligent"stimulus-response release system,multi-domain application and future challenges,etc.,aiming to provide valuable reference and enlightenment for researchers in this field.Promote the continuous innovation and development of small molecule self-assembly prodrug technology.