基于"肺主皮毛"理论的银屑病"药-罐-针-浴"结合模式的临床研究OA
Clinical Study on the Combined Treatment Mode of"Medication-Cupping-Acupuncture-Medicinal Bath"for Psoriasis Based on the Theory of"Lung Governs Fur"
目的:以"肺主皮毛"理论为指导,从肺论治银屑病,观察"药-罐-针-浴"结合模式的临床疗效及对外周血CD4+T淋巴细胞亚群及相关细胞因子水平的影响.方法:选取2023年9月—2024年10月就诊于徐州市中医院皮肤科的银屑病患者140例,随机分为观察组和对照组,各70例.观察组从肺论治,在内服中药汤剂基础上,予以拔罐、针刺及中药药浴治疗;对照组口服阿维A胶囊治疗.2组疗程均为8周,治疗前后均进行银屑病面积和严重程度指数(PASI)评分、CD4+T 淋巴细胞亚群及相关细胞因子水平检测,疗程结束后进行临床疗效及安全性评价.结果:2 组治疗后 PASI 评分均降低(P<0.05),且观察组降低幅度明显大于对照组(P<0.05).2 组治疗后外周血辅助性T淋巴细胞 1 型(Th1)、17 型(Th17)、22 型(Th22)比例,以及白细胞介素(IL)-17、IL-22、IL-23、肿瘤坏死因子-α(TNF-α)水平均下降,且观察组下降更显著(P<0.05);而调节性 T 细胞(Treg)及 IL-10 水平均升高,且观察组升高更明显(P<0.05).2 组总有效率比较,观察组为 89.23%,高于对照组的 78.13%(P<0.05).观察组不良反应发生率(4.62%)明显低于对照组(20.31%)(P<0.05).结论:银屑病从肺论治的"药-罐-针-浴"结合模式疗效显著,安全性高,值得临床推广应用.
Objective:Guided by the theory of"lung governs fur",this study aimed to treat psoriasis from the perspective of the lung and observe the clinical efficacy of the combined"medicine-cupping-acupuncture-medicinal bath"mode and its effects on peripheral blood CD4+T lymphocyte subsets and related cytokine levels.Methods:A total of 140 patients with psoriasis who visited the department of dermatology,Xuzhou Hospital of Traditional Chinese Medicine from September 2023 to October 2024 were enrolled and randomly divided into observation group and control group,with 70 cases in each group.The observation group was treated from the perspective of the lung,receiving oral Chinese herbal decoction,cupping therapy,acupuncture,and Chinese herbal medicine baths.The control group received oral acitretin capsules treatment.Both groups were treated for 8 weeks.Psoriasis area and severity index(PASI)scores,CD4+T lymphocyte subsets,and related cytokine levels were assessed before and after treatment.Clinical efficacy and safety evaluations were conducted at the end of the treatment course.Results:After treatment,the PASI scores of both groups decreased(P<0.05),and the decrease in the observation group was significantly greater than that in the control group(P<0.05).After treatment,both groups showed decreased levels of proportions of T helper lymphocyte Type 1(Th1),Type 17(Th17)and Type 22(Th22),as well as interleukin(IL)-17,IL-22,IL-23,and tumor necrosis factor-α(TNF-α)in peripheral blood,and the decreases were more significant in the observation group(P<0.05).Meanwhile,regulatory T cells(Treg)and IL-10 levels increased in both groups,and the increases were more pronounced in the observation group(P<0.05).Comparing the total effective rates between the two groups,the observation group was 89.23%,which was higher than the control group at 78.13%(P<0.05).The incidence of adverse reactions in the observation group(4.62%)was significantly lower than that in the control group(20.31%)(P<0.05).Conclusion:The combined"medicine-cupping-acupuncture-medicina bath"mode for the treatment of psoriasis from the perspective of the lung demonstrates significant efficacy and high safety,suggesting its potential for clinical application and promotion.
唐志铭;丁继存;王咏露;陆鹭;鹿晓兰;荆梦晴
徐州市中医院皮肤科 江苏 徐州 221003徐州市中心医院烧伤整形科 江苏 徐州 221100徐州市中医院皮肤科 江苏 徐州 221003徐州市中医院皮肤科 江苏 徐州 221003徐州市中医院皮肤科 江苏 徐州 221003徐州市中医院皮肤科 江苏 徐州 221003
医药卫生
银屑病从肺论治肺主皮毛临床研究
PsoriasisTreatment from the Perspective of the LungLung Governs FurClinical Research
《江西中医药大学学报》 2026 (3)
53-57,5
徐州市重点研发计划(社会发展)-临床前沿技术项目(KC23147).
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