名老中医治疗高脂血症医案的态靶辨治规律研究OA

Objective:Based on the state-targeted syndrome differentiation treatment theory proposed by Academician TONG Xiaolin,this study analyzes the patterns of state-targeted syndrome differentiation and treatment used by renowned traditional Chinese medicine practitioners in treating cases of hyperlipidemia using information technology methods.Methods:The state in the medical cases is identified by analyzing the syndrome differentiation and medication information within the cases.The target prescriptions and target medicines for treating hyperlipidemia are inferred using the main treatments and effects of the prescriptions and Chinese medicines,as well as the results of modern pharmacological research.The states treated by each prescription and Chinese medicine are analyzed based on their cold or hot properties and effects.Then,descriptive statistical analysis and association rule analysis are applied to summarize the distribution patterns of states,target prescriptions,and target medicines.Results:There are six states identified in hyperlipidemia cases.Based on the frequency and percentage of occurrence,the states are as follows:stasis state(73 cases,20.05%),deficiency state(70 cases,19.23%),congestion state(65 cases,17.86%),dampness state(60 cases,16.48%),heat state(54 cases,14.84%),and depression state(42 cases,11.54%).Results:There are 18 prescription formulas identified for adjusting states in hyperlipidemia.Their frequency and confidence levels are as follows:for treating stasis state,Xuefu Zhuyu Decoction(7 cases,77.78%),Taohong Siwu Decoction(2 cases,22.22%);for deficiency state,Liuwei Dihuang Pills(6 cases,46.15%),Danggui Buxue Decoction(4 cases,30.77%),Shengmai Powder(1 case,7.70%),Renshen Jianpi Pills(1 case,7.70%),Zhibai Dihuang Pills(1 case,7.70%);for congestion state,Erchen Decoction(6 cases,50.00%),Gualou Xiebai Banxia Decoction(3 cases,25.00%),Sijunzi Decoction(2 cases,16.67%),Wendan Decoction(1 case,8.3%);for dampness state,Wuling San(5 cases,71.42%),Zexie Decoction(1 case,14.29%),Chaiqin Decoction(1 case,14.29%);for heat state,Yinchenhao Decoction(1 case,25.00%),Simiao Pills(1 case,25.00%),Da Chaihu Decoction(1 case,25.00%),Danggui Liuhuang Decoction(1 case,25.00%);For hyperlipidemia,there are 16 commonly used medicinal herbs(appearing more than 10 times)with their frequencies and confidence levels as follows:For treating stasis state,Danshen(44 cases,74.58%),Chuanxiong(25 cases,42.37%),Chishao(14 cases,23.73%);for deficiency state,Huangqi(20 cases,34.48%),Dangshen(15 cases,25.86%),Gouqizi(12 cases,20.69%),Danggui(11 cases,18.97%),Niuxi(10 cases,17.24%);for congestion state,Banxia(14 cases,35.90%),Gualou(12 cases,30.77%),Shan Zha(10 cases,25.64%);for dampness state,Fuling(14 cases,35.00%),Baizhu(11 cases,27.50%),Zexie(10 cases,25.00%);for heat state,Sheng Di Huang(13 cases,37.14%);for depression state,Yujin(16 cases,53.33%).Conclusion:In the treatment of hyperlipidemia,renowned traditional Chinese medicine practitioners mainly address stasis and deficiency states,followed by congestion,dampness,and heat states,with depression states being relatively less common.According to the progression of the pathogenesis of hyperlipidemia,the early stages are characterized by congestion and depression states,the middle stages by dampness and heat states,and the later stages show deficiency and stasis states.Analyzing the medical cases of hyperlipidemia treated by renowned traditional Chinese medicine practitioners through the theory of state-targeted syndrome differentiation aids in making the empirical use of medicine by these practitioners more intuitive and data-driven,providing references for clinical diagnosis and treatment.