中国内脏脂肪指数与良性前列腺增生发病风险的关联性研究OA

Objective To investigate the predictive value of the Chinese visceral adiposity index(CVAI)for the progression of benign prostatic hyperplasia(BPH).Methods A total of 326 pa-tients with BPH were selected.Clinical data were collected at baseline,and the CVAI was calculat-ed.Patients were divided into three groups according to CVAI scores:low CVAI group(＜80 score,n=109),medium CVAI group(80-100 score,n=104),and high CVAI group(＞100 score,n=113).The severity of lower urinary tract symptoms(LUTS)was assessed using the International Prostate Symptom Score(IPSS),and prostate volume was measured by transrectal ultrasound.The above-mentioned indicators were repeatedly measured at 6,12,and 24 months of follow-up.A linear mixed model(LMM)was used to analyze the associations of CVAI groups with changes in IPSS scores and prostate volume over time,adjusting for covariates such as age,body mass index(BMI),fasting blood glucose,testosterone levels,and history of α-blocker use.Results There was no significant difference in age among the three groups(P＞0.05),while significant differences were observed in multiple indicators such as BMI and waist circumference(P＜0.05).The high CVAI group had significantly higher IPSS and prostate volume than the low CVAI group(P＜0.05).The linear mixed model showed that for each additional year of follow-up,the IPSS increased by 0.98-1.05 score,and the prostate volume increased by 0.51～0.53 mL.After full adjustment for confounding factors,the medium and high CVAI groups had IPSS that were 2.15 and 5.23 points higher,respec-tively,with annual deterioration rates that were 0.52 and 0.83 points higher,respectively.The pros-tate volumes were 3.32 and 7.58 mL larger,respectively,with annual growth rates increase by 0.32 and 0.41 mL,respectively,and the differences were statistically significant(P＜0.05).Moreover,a dose-response relationship was observed between CVAI and prostate volume.Conclusion Among patients with BPH,a high CVAI is significantly associated with accelerated deterioration of LUTS and rapid enlargement of prostate volume.CVAI can serve as a potential metabolic indicator for risk stratification of BPH progression.Implementing visceral fat control in patients with a high CVAI may delay the clinical progression of BPH.