枸杞多糖通过Nrf2通路对多器官保护的研究进展OA

Oxidative stress imbalance,as a common pathological basis for multi-system diseases such as cardiovascular diseases,nerve injury,metabolic liver disease,and sepsis-associated acute kidney injury(SA-AKI),is characterized by a vicious cycle of excessive reactive oxygen species(ROS)generation and insufficient endogenous antioxidant defense.Lycium barbarum polysaccharides(LBP),as the primary bioactive components of L.barbarum,have attracted significant attention in recent years in multi-organ protective effect research due to their medicinal and edible properties and multi-target regulatory advantages,particularly regarding their regulation of oxidative stress via the nuclear factor erythroid 2-related factor 2(Nrf2)pathway.This article,through a review of the literature retrieved from PubMed and China National Knowledge Infrastructure(CNKI)databases with the time interval from January 2010 to June 2025,systematically summarizes the protective effects and mechanisms of LBP against myocardial ischemia-reperfusion injury,ischemic stroke,alcoholic liver injury,SA-AKI,vascular retinopathy,and ultraviolet-induced skin damage.It aims to provide theoretical support for the clinical translation of LBP in long-term intervention of chronic diseases and the multi-target development of natural products.