新生儿低血糖多种临床特征与影响因素相关性OA

Objective To investigate influencing factors and predictive values of diverse clinical features of neonatal hypoglycemia(NH).Methods A total of 194 neonates with NH who admitted to Department of Internal Neonatology of Shanxi Children's Hospital from August 2021 to August 2023 were included in retrospective study.Multiple linear regression models were established to analyze relationships between different diverse clinical features of NH(first onset time of hypoglycemia,blood glucose value at first hypoglycemia onset,duration of hypoglycemia,the lowest value of blood glucose)and their influencing factors.Results The first NH onset times of the neonates of their mothers who suffered from hypertensive disorder of pregnancy(HDP)and hypocalcemia during pregnancy were later(β=1.153 and 1.882 respectively,both P<0.05),while that of the neonates of their mothers who suffered from gestational diabetes mellitus(GDM)was earlier(β=-0.859,P<0.05).The neonates with patent ductus arteriosus(PDA)had higher blood glucose value at first onset of NH(β=0.185,P<0.05),whereas those neonates who were fed initially with formula milk powder or the neonates had retinal hemorrhage had lower blood glucose values at first onset of NH(β=-0.220 and-0.619 respectively,both P<0.05).The duration of NH of these neonates with hypokalemia was longer(β=1.372,P<0.05),while the duration of NH of those neonates who were fed with formula milk powder was shorter compared to those neonates who received mixed feeding(β=-0.788,P<0.05).The lowest blood glucose value of the macrosomias was higher(β=0.506,P<0.05),whereas the lowest blood glucose values of those neonates whose mother suffered from preeclampsia,or the neonates had neonatal respiratory failure or retinal hemorrhage,and those neonates were fed with formula milk powder after birth were lower(β=-0.211,-0.317,-0.506 and-0.288 respectively,all P<0.05).Conclusion Neonate having respiratory failure,mother suffering from HDP,preeclampsia and GDM are all risk factors for occurrence of more severe NH.When mother's breast milk is insufficient,mixed feeding could be chosen,which is beneficial for preventing more severe NH and improving prognosis of the disease.