线粒体动力学在消化系统肿瘤"炎-癌"转化方面作用的研究进展OA

The"inflammation-cancer"transition denotes the biological process whereby chronic inflammatory microenviron-ments induce genomic instability,suppress immune surveillance,and activate carcinogenic signalling pathways,ultimately leading to abnormal cellular proliferation and malignant transformation.Mitochondria constitute fundamental organelles whose dynamic morphological alterations generate cellular fragments of varying lengths—a highly regulated process termed mitochondrial dynam-ics.Mitochondrial dynamics regulate cellular processes including the cell cycle,metabolism,survival,and death under both physi-ological and pathological conditions.Abnormal mitochondrial dynamics amplifies inflammatory signals,exacerbates oxidative stress,promotes cellular damage,and induces DNA mutations,being closely associated with the"inflammation-cancer"transfor-mation process in digestive system tumours.This paper systematically summarises the molecular mechanisms by which mitochon-drial dynamics facilitates"inflammation-cancer"conversion across different types of digestive system tumours.It aims to provide ex-perimental evidence and theoretical support for targeted anti-cancer therapies based on mitochondrial dynamics.