刺激响应型水凝胶在心脏组织工程中的应用研究OA

Cardiac tissue engineering aims to repair or regenerate damaged myocardial tissue by constructing functional myo-cardial substitutes.However,its progress has been limited by the inability of conventional biomaterials to dynamically replicate the heart's complex mechanical and electrophysiological microenvironment.Stimuli-responsive hydrogels(SRHs),as intelligent bio-materials,present a revolutionary solution by dynamically modulating their structural and functional properties in response to exter-nal physical stimuli(e.g.,temperature,light,mechanical forces)or chemical stimuli(e.g.,pH,enzymes,ions).These materials not only demonstrate exceptional biocompatibility and tunable mechanical properties but also mimic critical cardiac dynamics,in-cluding rhythmic tissue contractions,electrical signal propagation,and pathological microenvironmental changes.Such dynamic re-sponsiveness facilitates precise regulation of cellular behaviors(e.g.,cardiomyocyte alignment,angiogenesis)and promotes target-ed tissue regeneration.This review synthesizes cutting-edge research to systematically examine the design principles and functional characteristics of various SRHs,with a particular emphasis on their multifaceted application potential in cardiac tissue engineering.By establishing fundamental theoretical frameworks and technical references,this work provides critical insights for the develop-ment of next-generation intelligent myocardial repair materials.