血脂异常与良性前列腺增生/下尿路症状风险的关联:基于CHARLS的横断面与纵向研究OA

Objective To explore the correlation between dyslipidemia and benign prostatic hyperplasia(BPH)/lower urinary tract symptom(LUTS)risk.Methods A total of 5706 research subjects participated in the 2011 China Health and Retirement Longitudinal Study were enrolled in performing cross-sectional study,therein a total of 3326 participants who completed the follow-up in 2018 were included as the research subjects for performing longitudinal study.Multivariate Logistic regression was adopted to analyze the correlation between dyslipidemia and BPH/LUTS,and subgroup analysis and interactive effect analysis on age,educational level,household registration,marital status,nighttime sleep duration,and depression were conducted.Results The results of cross-sectional study revealed that in the completely adjusted model adjusting for all covariates,the risk of BPH/LUTS was significantly increased in patients with dyslipidemia(P<0.05).The results of longitudinal study indicated that in the completely adjusted model adjusting for all covariates,patients with dyslipidemia obtained a significantly increased risk of new-onset BPH/LUTS after 7 years of follow-up(P<0.05).The results of subgroup analysis depicted that the causal correlation between dyslipidemia and BPH/LUTS was statistically significant in the subgroups of age≥60 years,educational level below junior high school,urban household registration,and nighttime sleep duration<6 hours(P<0.05),whereas this correlation was not statistically significant in the subgroups of age between 45 and 60 years,with a junior high school education or above,rural household registration,and nighttime sleep duration between 6 and 8 hours or>8 hours(P>0.05);however,the results of the interactive effect test were not statistically significant(Pinteraction>0.05).Conclusion Dyslipidemia increases the occurrence risk of BPH/LUTS.Strengthening the screening and management of dyslipidemia may be of great significance for the early prevention of BPH/LUTS.