高频超声联合单核细胞红细胞比率评估乳腺癌新辅助化疗疗效价值分析OA
Analysis of the Value of High-frequency Ultrasound Combined with Monocyte-erythrocyte Ratio in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer
目的:探讨高频超声联合单核细胞红细胞比率(MRR)评估乳腺癌新辅助化疗(NAC)疗效的价值.方法:回顾性分析2022年1月至2024年12月期间收治的118例接受NAC的乳腺癌患者资料,依据NAC疗效将患者分为有效组(82例)与无效组(36例).进行NAC疗效相关因素的单因素分析;采用Logistic分析NAC疗效的影响因素;绘制受试者工作特征(ROC)曲线分析高频超声参数联合MRR对NAC疗效的判别价值.结果:两组患者在年龄、体质量指数(BMI)、绝经、高血压、糖尿病及临床分期方面无统计学差异(P＞0.05).化疗前,两组患者高频超声特征参数及MRR水平无统计学差异(P＞0.05).化疗后,有效组肿瘤最大径、阻力指数(RI)、收缩期峰值流速(PSV)及 MRR 均显著低于无效组(P＜0.05)[肿瘤最大径:(2.84±0.85)cm vs.(3.32±0.79)cm,RI:(0.41±0.12)vs.(0.62±0.14),PSV:(8.92±2.84)cm/s vs.(15.25±2.03)cm/s,MRR:(4.56±1.08)× 10-3 mmol/L vs.(6.62±1.45)× 10-3mmol/L].Logistic 分析结果显示,肿瘤最大径、RI、PSV及MRR均为NAC疗效的影响因素(P＜0.05).高频超声参数联合MRR判别NAC疗效的效能最高,其曲线下面积(AUC)为0.930(95％CI:0.867～0.968),敏感度和特异度分别为90.24％和77.78％,均优于各指标单独检测(P＜0.05).结论:高频超声参数联合MRR在评估乳腺癌NAC疗效方面具有良好价值,效能显著优于单一指标,可为临床疗效判断提供参考.
Objective:To investigate the utility of high-frequency ultrasound combined with the monocyte-to-erythrocyte ratio(MRR)in assessing the effectiveness of neoadjuvant chemotherapy(NAC)in breast cancer patients.Methods:A retrospective analysis was conducted on the data of 118 breast cancer patients who received NAC from January 2022 to December 2024.The patients were divided into the effective group(82 cases)and the ineffective group(36 cases)based on the therapeutic effect of NAC.A univariate analysis of the factors related to the efficacy of NAC was conducted;Logistic regression was used to analyze the influencing factors of the therapeutic effect of NAC;The receiver operating characteristic(ROC)curve was drawn to analyze the discriminative value of high-frequency ultrasound parameters combined with MRR for the therapeutic effect of NAC.Results:There were no differences between the two groups of patients in terms of age,body mass index(BMI),menopause,hypertension,diabetes and clinical stage(P＞0.05).Before chemotherapy,there was no difference in high-frequency ultrasound characteristic parameters and MRR levels between the two groups of patients(P＞0.05).After chemotherapy,the maximum tumor diameter,maximum tumor diameter,resistance index(RI),peak systolic velocity(PSV)and MRR in the effective group were significantly lower than those in the ineffective group(P＜0.05)[Maximum tumor diameter:(2.84±0.85)cm vs.(3.32±0.79)cm,RI:(0.41±0.12)vs.(0.62±0.14),PSV:(8.92±2.84)cm/s vs.(15.25±2.03)cm/s,MRR:(4.56±1.08)× 10-3 mmol/L vs.(6.62±1.45)× 10-3 mmol/L].The results of Logistic analysis showed that the maximum diameter of the tumor,RI,PSV and MRR were all influencing factors affecting the efficacy of NAC(P＜0.05).The efficacy of high-frequency ultrasound parameters combined with MRR in discriminating the therapeutic effect of NAC was the highest.The area under the curve(AUC)was 0.930(95％CI:0.867～0.968),and the sensitivity and specificity were 90.24％and 77.78％respectively,both of which were superior to the individual detection of each index(P＜0.05).Conclusion:High-frequency ultrasound parameters combined with MRR have good value in evaluating the efficacy of NAC in breast cancer,and its efficacy is significantly better than that of a single indicator,which can provide a reference for clinical efficacy judgment.
刘璐;庞海宝;王丹丹
唐山市中医医院彩超室,河北 063000唐山市中医医院彩超室,河北 063000唐山市中医医院外科,河北 063000
医药卫生
乳腺癌新辅助化疗高频超声单核细胞红细胞比率疗效评估
breast cancerneoadjuvant chemotherapyhigh-frequency ultrasoundmonocyte-to-erythrocyte ratioeffect evaluation
《影像科学与光化学》 2026 (4)
11-16,23,7
河北省2024年度中医药类科学研究课题计划项目(2024432).
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