SUMO化修饰及其在免疫调控中的多维作用OA

Small molecule ubiquitin-like modification(SUMO)is a dynamic and reversible post-translational modification that profoundly regulates immune and inflammatory responses by precisely modulating the activity,localization and interactions of substrate proteins.Elucidates the dual roles of SUMOylation modification and its inhibition in immune regulation.On one hand,SUMOylation can exert anti-inflammatory and homeostatic functions by promoting the assembly of inhibitory complexes,restricting the expression of inflammatory genes,and driving macrophage polarization towards the M2 anti-inflammatory phenotype.On the other hand,it can also exacerbate inflammation through mechanisms such as stabilizing the NLRP3 inflammasome and promoting Th17 cell differentiation.Conversely,the inhibition mediated by SUMOylation typically relieves the negative regulation of innate immune signaling pathways,such as the type I interferon pathway,thereby enhancing antiviral and antitumor immunity,however,in specific contexts,it may also activate anti-inflammatory pathways.The analysis of this regulatory mechanism not only advances understanding of the dynamic immune regulatory network but also provides molecular targets and potential therapeutic strategies for the targeted intervention of infectious diseases,autoimmune disorders and cancers,thereby facilitating the translation of basic immunological research into clinical applications.