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基于nnU-Net的肾脏区域分割方法及其术中应用OA

Kidney region segmentation method based on nnU-Net and its intraoperative application

中文摘要英文摘要

目的 探索基于nnU-Net的深度学习方法在肾脏手术中的应用,特别是术中图像分割的可行性.随着肾脏肿瘤手术的复杂性增加,精准的术中图像分割成为手术导航的关键.研究目标是通过nnU-Net框架,提高术中肾脏区域的自动识别和定位精度,从而为智能辅助手术系统提供技术支持.方法 基于术中获取的左目内镜图像,采用nnU-Net框架构建了二维语义分割模型.训练数据通过逐帧截取术中图像,并结合手工掩码标注生成.标注区域包括肾脏实质、肿瘤及表面粘连脂肪,作为一个统一的感兴趣区域(region of interest,ROI)进行识别.在数据验证方面,使用了独立的测试集,包括未参与训练和验证的5例肾脏手术病例,最终通过与人工标注的掩码进行对比分析,以评估模型在术中图像分割中的表现.结果 模型在独立测试集中表现良好,平均 Dice相似系数(Dice similarity coefficient,DSC)为0.933 5,交并比(intersection over union,IoU)为0.878 4,精确率(precision)为0.951 7,召回率(recall)为0.921 1,F1 分数(F1 score)为0.933 5.nnU-Net能够有效地分割肾脏区域,并在不同情况下保持较高的分割精度.推理速度方面,模型的平均单帧分割时间约为0.38 s,显示出较强的处理能力,适用于术中快速图像更新与定位识别需求.结论 nnU-Net模型在复杂术中图像环境中依然保持较高的准确性与鲁棒性,验证了nnU-Net在实时图像分割任务中的应用潜力.nnU-Net可以为智能辅助手术系统提供可靠的技术支撑,具有较好的临床应用前景.

Objective Explore the application of deep learning methods based on nnU-Net in kidney surgery,particularly the feasibility of intraoperative image segmentation.As the complexity of kidney tumor surgery increases,precise intraoperative image segmentation becomes crucial for surgical navigation.The research goal is to improve the automatic recognition and localization accuracy of the renal region during surgery using the nnU-Net framework,thereby providing technical support for intelligent assisted surgery systems.Methods Based on the left-eye endoscopic images obtained during surgery,a 2D semantic segmentation model was constructed using the nnU-Net framework.The training data were generated by extracting individual frames from the intraoperative images and combining them with manually annotated masks.The annotated regions include renal parenchyma,tumors,and surface-adhered fat,which were identified as a unified region of Interest(ROI).For data validation,an independent test set was used,consisting of five kidney surgery cases that did not participate in the training and validation.The model's performance in intraoperative image segmentation was evaluated by comparing it with manually annotated masks.Results The model performed well on the independent test set,with an average Dice similarity coefficient(DSC)of 0.9335,intersection over union(IoU)of 0.878 4,precision of 0.951 7,recall of 0.921 1,and F1 score of 0.933 5.These results indicate that nnU-Net can effectively segment the renal region and maintain high segmentation accuracy under various conditions.In terms of inference speed,the average single-frame segmentation time of the model is approximately 0.38 seconds,demonstrating strong processing capability,making it suitable for rapid intraoperative image updates and localization tasks.Conclusions The nnU-Net model maintains high accuracy and robustness even in complex intraoperative image environments,validating its potential for real-time image segmentation tasks.nnU-Net can provide reliable technical support for intelligent assisted surgery systems,showing promising clinical application prospects.

王文韬;张海康;黄清明;黄亦成;徐天宇;胡敏捷;沈兵

上海理工大学健康科学与工程学院(上海 200093)上海理工大学健康科学与工程学院(上海 200093)||上海理工大学上海介入医疗器械工程技术研究中心(上海 200093)上海理工大学健康科学与工程学院(上海 200093)||上海健康医学院医学影像学院(上海 201318)上海理工大学健康科学与工程学院(上海 200093)||同济大学附属第十人民医院泌尿外科(上海 200072)上海理工大学健康科学与工程学院(上海 200093)||上海申康医院发展中心(上海 200041)上海理工大学健康科学与工程学院(上海 200093)上海理工大学健康科学与工程学院(上海 200093)||上海理工大学上海介入医疗器械工程技术研究中心(上海 200093)||同济大学附属第十人民医院泌尿外科(上海 200072)

医药卫生

深度学习图像分割肾脏区域术中图像nnU-Net

deep learningimage segmentationkidney regionintraoperative imagennU-Net

《北京生物医学工程》 2026 (3)

221-228,246,9

10.3969/j.issn.1002-3208.2026.03.001

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