七宝美髯丹联合高能窄谱640nm红光治疗斑秃疗效观察OA
Clinical Observation on the Efficacy of Qibao Meiran Dan Combined with High-energy Narrow-Spectrum 640nm Red Light Therapy for Alopecia Areata
目的:探讨七宝美髯丹联合高能窄谱 640nm 红光治疗肝肾不足型斑秃的疗效机制.方法:选取 80 例肝肾不足型斑秃患者,随机数字表法分为对照组 40 例,观察组 40 例.对照组予 2%米诺地尔搽剂联合高能窄谱 640nm 红光治疗;观察组予七宝美髯丹联合高能窄谱 640nm 红光治疗,2 组疗程均为 3 月,比较 2 组治疗前后脱发严重程度(SALT)评分、情绪抑郁(SDS)评分及外周血 25-羟基维生素 D[25(OH)D]水平以评估疗效,观察不良反应.结果:2 组 SALT、SDS 评分均较治疗前降低(P<0.01),外周血 25(OH)D 水平较治疗前升高(P<0.01),且观察组上述指标改善幅度均优于对照组(P<0.05);观察组治疗总有效率(80.0%)高于对照组(65.0%),差异有统计学意义(χ2=4.178,P<0.05).且 2 组治疗观察期间均未出现严重不良反应事件,组间差异(P>0.05).结论:七宝美髯丹联合高能窄谱640nm 红光治疗斑秃安全可靠,能有效减轻患者脱发症状,改善抑郁情绪,增强机体免疫,值得临床应用.
Objective:To investigate the efficacy mechanism of Qibao Meiran Dan combined with high-energy nar-row-band 640nm red light therapy for alopecia areata caused by liver and kidney deficiency.Methods:Eighty patients with alopecia areata caused by liver and kidney deficiency were randomly divided into a control group(n=40)and an observation group(n=40).The control group received 2%minoxidil lotion combined with high-energy narrow-band 640nm red light therapy;the observation group received Qibao Meiran Dan combined with high-energy narrow-band 640nm red light therapy.The treatment course for both groups was 3 months.The severity of hair loss(SALT)score,depression score(SDS)score,and peripheral blood 25-hydroxyvitamin D[25(OH)D]level were compared before and after treatment to evaluate the efficacy and observe adverse reactions.Results:SALT and SDS scores in both groups decreased compared to pre-treatment levels(P<0.01),while peripheral blood 25(OH)D levels increased(P<0.01),with the observation group showing greater improvement than the control group(P<0.05).The total effective rate in the ob-servation group(80.0%)was significantly higher than that in the control group(65.0%)(χ2=4.178,P<0.05).No serious adverse events occurred in either group during the treatment period(P>0.05).Conclusion:Qibao Meiran Dan combined with high-energy narrow-spectrum 640nm red light therapy is safe and reliable for treating alopecia areata,effectively alleviating hair loss symptoms,improving depressive mood,and enhancing immunity,making it worthy of clinical ap-plication.
马慧琳;荣光辉;胡静
安徽中医药大学附属六安市中医院 安徽 六安 237006安徽中医药大学附属六安市中医院 安徽 六安 237006安徽省六安市金安区中医医院 安徽 六安 237156
医药卫生
七宝美髯丹高能窄谱640nm红光斑秃临床研究
Qibao Meiran Danhigh-energy narrow-spectrum 640nm red lightalopecia areataclinical research
《中医药临床杂志》 2026 (5)
1060-1064,5
六安市科技计划项目(2023lakj-zyy020)
评论