Mechanisms of anticancer active molecules from traditional Chinese medicine and strategies for clinical applicationOA
Traditional Chinese medicine(TCM)is a valuable source of bioactive molecules,whose potential to alter oncogenic processes associated with cancer includes aberrant proliferation,apoptotic resistance,and metastatic reprogramming.This article is a systematic review on the mechanistic basis of anticancer TCM-derived compounds,mainly flavonoids,terpenoids,and polysaccharides.We focus on literature from 2005 till now.The TCM compounds described here are capable of inducing caspase-mediated apoptosis,inhibiting the PI3K/Akt/mTOR and Wnt/β-catenin signalling pathways,inhibiting epithelial-mesenchymal transition(EMT),enhancing NK cell cytotoxicity,and repolarizing tumor-associated macrophages(TAMs)in the tumor microenvironment(TME).The compounds,however,show promise in the preclinical and early clinical settings.The integration of TCM with western medicines raises challenges that require attention.These are poor bioavailability,incomplete mechanism understanding,and a lack of standardization.Our analysis indicates that TCM bioactives could potentially be used as new agents in precision oncology for resistant cancers.We additionally propose that the marriage of systems biology with adaptive clinical trial designs may accelerate their translation into next-generation anticancer regimens,with TCM poised to play a complementary cornerstone in modern oncology.
Xiang-Zan Wei;Jing-Mei Yao;Shu-Xin Liang;Yu-Yan Wang;Jia-Yi Wang;Piao-Liu Yuan;Xian Zhou;Wei-Rong Qin
Education Department of Guangxi Zhuang Autonomous Region,Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University),Nanning 530021,China School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,ChinaEducation Department of Guangxi Zhuang Autonomous Region,Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University),Nanning 530021,China School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,ChinaEducation Department of Guangxi Zhuang Autonomous Region,Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University),Nanning 530021,China School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,ChinaEducation Department of Guangxi Zhuang Autonomous Region,Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University),Nanning 530021,China School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,ChinaEducation Department of Guangxi Zhuang Autonomous Region,Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University),Nanning 530021,China School of Basic Medical Sciences,Guangxi Medical University,Nanning 530021,ChinaDepartment of Pediatrics,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,ChinaDepartment of Pediatrics,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,ChinaEducation Department of Guangxi Zhuang Autonomous Region,Key Laboratory of Biological Molecular Medicine Research(Guangxi Medical University),Nanning 530021,China Pharmaceutical College,Guangxi Medical University,Nanning 530021,China Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation,Guangxi Medical University,Nanning 530021,China
医药卫生
traditional Chinese medicineanticancer active moleculesmechanisms of actionclinical applicationresearch strategies
《Traditional Medicine Research》 2026 (10)
P.59-73,15
the Natural Science Foundation of Guangxi Province(Nos.2025GXNSFBA069259,2025GXNSFBA069470 and 2026GXNSFAA00640989)the National Natural Science Foundation of China(Grant No.22467006)Additional support was provided by the Scientific Research Fund of the Guangxi Education Department(Grant No.2023KY0124)the Education Department of Guangxi Zhuang Autonomous Region(Grant No.GXSWFZ202302)the Young Elite Scientists Sponsorship Program of GXAST(Grant No.2025YESSGX203).
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