Current research status on the role of natural product polyphenols in anti-liver injuryOA
Liver injury is a widespread global health concern characterized by a complex etiology and limited therapeutic alternatives,underscoring the urgent need for novel hepatoprotective agents.Natural polyphenolic compounds,including phenolic acids,flavonoids,and stilbenes,are abundantly found in traditional Chinese medicine and various natural products.In recent years,polyphenols have shown remarkable potential in ameliorating liver injury and associated disorders,owing to their potent antioxidant,anti-inflammatory,and metabolic regulatory properties.Although existing reviews have examined the hepatoprotective effects of polyphenols,systematic studies that comprehensively classify polyphenols derived from plants,animals,and fungi remain insufficient.This review elucidates the mechanisms by which natural polyphenols mitigate liver injury,focusing on their protective effects through the regulation of inflammatory responses,oxidative stress,mitochondrial dysfunction,apoptosis,and autophagy.It also analyzes the relationship between the structural diversity of polyphenols(e.g.,catechol structures,stilbene derivatives such as resveratrol,and phenolic acids)and their biological activity.Furthermore,this review highlights the emerging role of the gut-liver axis in mediating the effects of polyphenol metabolites,while acknowledging the limitations in current research regarding bioavailability,clinical translation,and the synergistic effects of polyphenols.Future research directions are proposed to provide theoretical foundations and practical references for the development of innovative hepatoprotective drugs.
Ting-Ting Zhang;Xiao-Wei Dai;Chen Xu;Hong-Yan Pei;Jia Zhou;Zhong-Mei He;Liang-Liang Weng
College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,ChinaReproductive Medical Center,Department of Obstetrics and Gynecology,The Second Norman Bethune Hospital of Jilin University,Changchun 130000,ChinaUniversity of the West of England College,Hainan Medical University,Haikou 570000,ChinaCollege of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,ChinaCollege of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,ChinaCollege of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,ChinaDepartment of Infectious Diseases,The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou 324000,China
医药卫生
polyphenolsliver injuryresearch progressnatural products
《Traditional Medicine Research》 2026 (10)
P.74-91,18
funded by Jilin Science and Technology Development Talent Special Project:study on the key technology and industrialization of chelating calcium from deer tendon under grant(20240601086RC)study on key technology and industrialization of deer heart peptide product,a special diet that can increase exercise endurance(23JQ08)Jilin Provincial Science and Technology Development Program Project Task-Jilin Provincial Key Laboratory of International Cooperation on Efficient Breeding and Product Development of Sika Deer(YDZJ202502CXJD077)projects under the Changchun Municipal Science and Technology Development Programme(2025ZDYFNS06).
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