Recent advances in collagen-based barrier membrane for guided bone regenerationOA
Guided bone regeneration(GBR)is a widely used clinical technique for bone reconstruction.The core of GBR technology is the GBR barrier membranes,which not only possess good barrier performance to effectively block the invasion of rapidly growing fibroblasts into osteoblasts,but also provide a favorable microenvironment for osteoblasts.Collagen-based GBR barrier membrane as one of the most important absorbable membranes has gained widespread clinical application due to its good biocompatibility,low immunogenicity and biodegradability.However,pure collagen has application defects such as low mechanical strength,rapid biodegradation,and susceptibility to microbial contamination,which require physical,chemical and biological crosslinking modification methods to expand its applications.In addition,antibacterial and antioxidant drugs,metal ions and growth factors are often introduced into collagen matrix to fabricate collagen-based barrier membranes by electrospinning,porogenic leaching,emulsion template method,and lyophilisation technologies.In terms of structural innovation of collagen-based barrier membranes,the monolayer,bilayer and multilayer barrier membranes have been developed to prevent fibroblast infiltration and create a favorable space for osteoblast growth.This review provided an overview of the crosslinking methods,molding techniques,and functional enhancement strategies of collagen-based GBR barrier membrane,with the aim of providing references for the future development and clinical application of novel collagen-based GBR barrier membrane.
Xue-Ping Liu;Zhi-Lang Xu;Yi-Ruo He;Li-Ming Ge;Ji-Min Guo;Chang-Dao Mu;De-Fu Li
Department of Pharmaceutics and Bioengineering,School of Chemical Engineering,Sichuan University,Chengdu 610065,ChinaDepartment of Pharmaceutics and Bioengineering,School of Chemical Engineering,Sichuan University,Chengdu 610065,ChinaWest China Hospital of Stomatology,Sichuan University,Chengdu 610041,ChinaDepartment of Pharmaceutics and Bioengineering,School of Chemical Engineering,Sichuan University,Chengdu 610065,ChinaState Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology,Beijing 100029,China Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology),Ministry of Education,Beijing 100029,China Beijing Laboratory of Biomedical Materials,College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing 100029,ChinaDepartment of Pharmaceutics and Bioengineering,School of Chemical Engineering,Sichuan University,Chengdu 610065,ChinaDepartment of Pharmaceutics and Bioengineering,School of Chemical Engineering,Sichuan University,Chengdu 610065,China
医药卫生
guided bone regenerationbarrier membranecollagencrosslinkingheterogeneous structure
《Biomedical Engineering Communications》 2026 (4)
P.5-22,18
supported by the National Natural Science Foundation of China(22578288,22505169)Natural Science Foundation of Beijing Municipality(L244036)Beijing Natural Science Foundation(Z250013)Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202105)the Fundamental Research Funds for the Central Universities(buctrc202319).
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