不同频率经皮电刺激联合透明质酸钠滴眼液治疗干眼症疗效研究OA
Efficacy study of different frequency percutaneous electrical stimulation combined with sodium hyaluronate eye drops in the treatment of dry eye syndrome
目的 评价不同频率经皮电刺激联合透明质酸钠滴眼液治疗干眼症患者的临床疗效.方法 选取2024年12月至2025年12月毕节市中医医院收治的99例干眼症患者作为研究对象,采用随机数字表法分为对照组(n=25)和试验组[低频组(n=25)、中频组(n=25)、高频组(n=24)].对照组给予透明质酸钠滴眼液治疗,试验组在此基础上联合不同频率经皮电刺激治疗,连续干预4周.分别于治疗前(基线)、治疗2周及4周评估受试患者的眼表疾病指数(ocular surface disease index,OSDI)、非接触式泪膜破裂时间(non-invasive tear breakup time,NITBUT)、泪液分泌试验(Schirmer I test,SIT)及眼部疼痛评分(numeric rating scale,NRS).采用重复测量方差分析比较各组患者随时间的变化情况.结果 重复测量方差分析结果显示,各组OSDI、NITBUT、SIT及NRS评分均存在显著时间主效应(P<0.001).在NITBUT、SIT及NRS指标中,时间×组别交互效应具有统计学意义(P<0.05).4周终点时,高频组患者在改善泪膜稳定性、泪液分泌及缓解眼部疼痛方面均优于对照组(P<0.001).结论 经皮电刺激联合透明质酸钠滴眼液可明显改善干眼症患者的主观症状及客观体征,其中相对较高频率的经皮电刺激在改善泪膜稳定性、泪液分泌及眼部疼痛方面显示出一定的临床优势.
Objective To evaluate the clinical efficacy of transcutaneous electrical stimulation at different frequencies combined with sodium hyaluronate eye drops in patients with dry eye syndrome.Methods A total of 99 patients with dry eye syndrome admitted to Bijie Hospital of Traditional Chinese Medicine from December 2024 to December 2025 were selected as subjects.They were randomly assigned into control group(n=25)and experimental groups[low-frequency group(n=25),medium-frequency group(n=25),high-frequency group(n=24)]using a random number table.The control group received sodium hyaluronate eye drops for treatment,while the experimal groups received combined therapy with different frequencies of transcutaneous electrical stimulation on this basis,with continuous intervention lasting 4 weeks.The ocular surface disease index(OSDI),non-invasive tear breakup time(NITBUT),Schirmer I test(SIT),and numerical rating scale(NRS)were assessed before treatment baseline,at 2 weeks,and at 4 weeks for all groups.Results Repeated-measurement ANOVA results showed significant time main effects for the OSDI,NITBUT,SIT,and NRS scores across all groups(P<0.001).Among the NITBUT,SIT,and NRS indicators,the time×group interaction effect was statistically significant(P<0.05).At the 4-week endpoint compared to control group,tear film stability,tear secretion,and ocular pain relief were superior improved in high-frequency group(P<0.001).Conclusion Percutaneous electrical stimulation combined with sodium hyaluronate eye drops significantly improves both subjective symptoms and objective signs in patients with dry eye syndrome.Notably,higher-frequency percutaneous electrical stimulation demonstrates clinical advantages in enhancing tear film stability,increasing tear secretion,and alleviating ocular pain.
郭佩颖;王丹靖;王畅;余萍
贵州中医药大学研究生院护理学院,贵州 贵阳 550002贵州中医药大学研究生院护理学院,贵州 贵阳 550002毕节市中医医院眼科,贵州 毕节 551700毕节市中医医院眼科,贵州 毕节 551700
医药卫生
干眼症经皮电刺激透明质酸钠眼表疾病指数
Dry eye syndromePercutaneous electrical stimulationSodium hyaluronateOcular surface disease index
《中国现代医生》 2026 (14)
56-59,4
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